Time-varying lung ventilation analysis of 4DCT using image registration

Kai Ding, Kaifang Du, Kunlin Cao, Gary E. Christensen, Joseph M. Reinhardt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Imaging techniques for measuring lung ventilation are essential tools to study lung tissue response to radiation therapy. Most of the existing CT and image registration based ventilation measurement methods use two extreme phases (end expiration and end inspiration) while ignoring the important ventilation variation within the respiratory cycle. In this paper, we present a new instantaneous ventilation measurement scheme using multiple 4DCT phase images and regularized 3D image registration, which aims at measuring the regional ventilation within the respiratory cycle. The ventilation is measured using the Jacobian (a function of local partial derivatives) of the registration displacement field. For all four animals, 39% of the total lung volume reaches maximum ventilation at T2 (50% inspiration phase) during inspiration and the 75% of the total lung volume reaches maximum ventilation at T 5 (75% expiration phase) during expiration. The registration accuracy assessed by 200 semi-automatically matched landmarks in all phases and animals show landmark error on the order of 1 mm after registration.

Original languageEnglish (US)
Title of host publication2011 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2011 - Proceedings
Pages5772-5775
Number of pages4
DOIs
StatePublished - Aug 18 2011
Externally publishedYes
Event36th IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2011 - Prague, Czech Republic
Duration: May 22 2011May 27 2011

Publication series

NameICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings
ISSN (Print)1520-6149

Other

Other36th IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2011
CountryCzech Republic
CityPrague
Period5/22/115/27/11

Keywords

  • image registration
  • pulmonary
  • radiation therapy
  • ventilation

ASJC Scopus subject areas

  • Software
  • Signal Processing
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Time-varying lung ventilation analysis of 4DCT using image registration'. Together they form a unique fingerprint.

Cite this