Time varying elastance and cardiac muscle energetics based on calcium kinetics and crossbridges cycling

Amir Landesberg, Rafael Beyar, Samuel Sideman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The study relates to the control of the mechanical activity of the cardiac muscle by coupling calcium kinetics with crossbridge cycling. Two main feedback mechanisms affect the performance of the contractile filaments: 1) cooperativity, in which the affinity of troponin for calcium is a function of the number of cycling crossbridges, and 2) mechanical feedback, where the velocity of filament sliding affects crossbridge turnover rate from the strong to the weak conformation. This intracellular control mechanism describes the performances of the skinned and intact cardiac muscle at various loading conditions, i.e. the force-length and the force-velocity relationships and the control of relaxation. The model can also describe the effect of various loading conditions on the work and ATP consumption. Using this approach, a mechanism for the time varying elastance of the left ventricle (LV) is proposed.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
PublisherPubl by IEEE
Pages373-376
Number of pages4
ISBN (Print)0818654708
StatePublished - 1993
Externally publishedYes
EventProceedings of the 1993 Conference on Computers in Cardiology - London, UK
Duration: Sep 5 1993Sep 8 1993

Other

OtherProceedings of the 1993 Conference on Computers in Cardiology
CityLondon, UK
Period9/5/939/8/93

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

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