Time to clearance of human papillomavirus infection by type and human immunodeficiency virus serostatus

Jill E. Koshiol, Jane C. Schroeder, Denise J. Jamieson, Stephen W. Marshall, Ann Duerr, Charles M. Heilig, Keerti V. Shah, Robert S. Klein, Susan Cu-Uvin, Paula Schuman, David Celentano, Jennifer S. Smith

Research output: Contribution to journalArticlepeer-review

Abstract

Persistent infection with high-risk human papillomavirus (HPV) is central to cervical carcinogenesis. Certain high-risk types, such as HPV16, may be more persistent than other HPV types, and type-specific HPV persistence may differ by HIV serostatus. This study evaluated the association between HPV type and clearance of HPV infections in 522 HIV-seropositive and 279 HIV-seronegative participants in the HIV Epidemiology Research Study (HERS, United States, 1993-2000). Type-specific HPV infections were detected using MY09/MY11/HMB01-based PCR and 26 HPV type-specific probes. The estimated duration of type-specific infections was measured from the first HPV-positive visit to the first of two consecutive negative visits. Hazard ratios (HRs) and 95% confidence intervals (CIs) for HPV clearance were calculated using Cox models adjusted for study site and risk behavior (sexual or injection drugs). A total of 1,800 HPV infections were detected in 801 women with 4.4 years median follow-up. HRs for clearance of HPV16 and related types versus low-risk HPV types were 0.79 (95% CI: 0.64-0.97) in HIV-positive women and 0.86 (95% CI: 0.59-1.27) in HIV-negative women. HRs for HPV18 versus low-risk types were 0.80 (95% CI: 0.56-1.16) and 0.57 (95% CI: 0.22-1.45) for HIV-positive and -negative women, respectively. HPV types within the high-risk category had low estimated clearance rates relative to low-risk types, but HRs were not substantially modified by HIV serostatus.

Original languageEnglish (US)
Pages (from-to)1623-1629
Number of pages7
JournalInternational Journal of Cancer
Volume119
Issue number7
DOIs
StatePublished - Oct 1 2006

Keywords

  • HIV
  • HPV type
  • Human
  • Papillomavirus
  • Time to clearance

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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