Time-Series Analysis of Meningococcal Disease in Catalonia

Angela Domínguez, Pilar Muñoz, Neus Cardeñosa, Ana Martínez, Joan Caylà

Research output: Contribution to journalArticle

Abstract

Purpose: In Catalonia, a region in the northeast of Spain, a rate of five cases of meningococcal disease per 100,000 inhabitants was reported during the period of 1996-1997, which was higher than in previous years. The objective of this study was to analyze the temporal behavior of serogroup B and C meningococcal disease cases in Catalonia. Methods: The study included confirmed cases of meningococcal disease from the 4-week period 11 of 1996 to the 4-week period 10 of 2004. A Poisson regression model (GLM) was fit for time series of serogroup B cases, whereas a zero-inflated Poisson model (ZIP) was necessary to adjust time series of serogroup C cases. Results: The evolution of cases in both serogroups was correlated over time. For serogroup B, there was also an association with the influenza epidemics reported in four of the seasons analyzed. For serogroup C, a positive association with three influenza epidemics and a negative association with vaccination campaigns were found. Time series analysis of meningococcal disease shows that serogroups B and C behave in a different way. Conclusions: The study of the evolution of each serogroup may be useful in evaluating vaccination strategies.

Original languageEnglish (US)
Pages (from-to)654-662
Number of pages9
JournalAnnals of epidemiology
Volume17
Issue number9
DOIs
StatePublished - Sep 1 2007

Keywords

  • Meningococcal disease
  • Serogroup B, Serogroup C
  • Time-series analysis

ASJC Scopus subject areas

  • Epidemiology

Fingerprint Dive into the research topics of 'Time-Series Analysis of Meningococcal Disease in Catalonia'. Together they form a unique fingerprint.

  • Cite this

    Domínguez, A., Muñoz, P., Cardeñosa, N., Martínez, A., & Caylà, J. (2007). Time-Series Analysis of Meningococcal Disease in Catalonia. Annals of epidemiology, 17(9), 654-662. https://doi.org/10.1016/j.annepidem.2007.03.006