Time-of-flight precision and PET image accuracy

Jeffrey A. Kolthammer; Jing Tang; Amy E. Perkins; Raymond F. Muzic

doi:10.1109/NSSMIC.2010.5874495

Time-of-flight precision and PET image accuracy

Jeffrey A. Kolthammer, Jing Tang, Amy E. Perkins, Raymond F. Muzic

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Time of flight information is used in PET to improve image quality. However, the nature of the improvement and its relationship with the precision of the time of flight measurement remains to be well-characterized, particularly in the framework of iterative reconstruction. In this work, hot-spheres phantoms are imaged, and the list data are then degraded to simulate systems with poorer timing resolution. More precise of flight is found to lead to images with higher sphere contrast and lower background noise at each iteration, and convergent sphere contrast with fewer iterations. Combining these effects, the background noise at which each sphere reaches 90% of its final contrast is lower with improved timing resolution, with the amount of noise reduction underestimated by a conventional proportionality to the timing resolution.

Original language	English (US)
Title of host publication	IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010
Pages	3657-3660
Number of pages	4
DOIs	https://doi.org/10.1109/NSSMIC.2010.5874495
State	Published - Dec 1 2010
Event	2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010 - Knoxville, TN, United States Duration: Oct 30 2010 → Nov 6 2010

Publication series

Name	IEEE Nuclear Science Symposium Conference Record
ISSN (Print)	1095-7863

Other

Other	2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010
Country	United States
City	Knoxville, TN
Period	10/30/10 → 11/6/10

ASJC Scopus subject areas

Radiation
Nuclear and High Energy Physics
Radiology Nuclear Medicine and imaging

Access to Document

10.1109/NSSMIC.2010.5874495

Fingerprint Dive into the research topics of 'Time-of-flight precision and PET image accuracy'. Together they form a unique fingerprint.

Cite this

Kolthammer, J. A., Tang, J., Perkins, A. E., & Muzic, R. F. (2010). Time-of-flight precision and PET image accuracy. In IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010 (pp. 3657-3660). [5874495] (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2010.5874495

Kolthammer, JA, Tang, J, Perkins, AE & Muzic, RF 2010, Time-of-flight precision and PET image accuracy. in IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010., 5874495, IEEE Nuclear Science Symposium Conference Record, pp. 3657-3660, 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010, Knoxville, TN, United States, 10/30/10. https://doi.org/10.1109/NSSMIC.2010.5874495

@inproceedings{c90ffb33b012442289236873d851ef4e,

title = "Time-of-flight precision and PET image accuracy",

abstract = "Time of flight information is used in PET to improve image quality. However, the nature of the improvement and its relationship with the precision of the time of flight measurement remains to be well-characterized, particularly in the framework of iterative reconstruction. In this work, hot-spheres phantoms are imaged, and the list data are then degraded to simulate systems with poorer timing resolution. More precise of flight is found to lead to images with higher sphere contrast and lower background noise at each iteration, and convergent sphere contrast with fewer iterations. Combining these effects, the background noise at which each sphere reaches 90% of its final contrast is lower with improved timing resolution, with the amount of noise reduction underestimated by a conventional proportionality to the timing resolution.",

author = "Kolthammer, {Jeffrey A.} and Jing Tang and Perkins, {Amy E.} and Muzic, {Raymond F.}",

year = "2010",

month = dec,

day = "1",

doi = "10.1109/NSSMIC.2010.5874495",

language = "English (US)",

isbn = "9781424491063",

series = "IEEE Nuclear Science Symposium Conference Record",

pages = "3657--3660",

booktitle = "IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010",

note = "2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010 ; Conference date: 30-10-2010 Through 06-11-2010",

}

TY - GEN

T1 - Time-of-flight precision and PET image accuracy

AU - Kolthammer, Jeffrey A.

AU - Tang, Jing

AU - Perkins, Amy E.

AU - Muzic, Raymond F.

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Time of flight information is used in PET to improve image quality. However, the nature of the improvement and its relationship with the precision of the time of flight measurement remains to be well-characterized, particularly in the framework of iterative reconstruction. In this work, hot-spheres phantoms are imaged, and the list data are then degraded to simulate systems with poorer timing resolution. More precise of flight is found to lead to images with higher sphere contrast and lower background noise at each iteration, and convergent sphere contrast with fewer iterations. Combining these effects, the background noise at which each sphere reaches 90% of its final contrast is lower with improved timing resolution, with the amount of noise reduction underestimated by a conventional proportionality to the timing resolution.

AB - Time of flight information is used in PET to improve image quality. However, the nature of the improvement and its relationship with the precision of the time of flight measurement remains to be well-characterized, particularly in the framework of iterative reconstruction. In this work, hot-spheres phantoms are imaged, and the list data are then degraded to simulate systems with poorer timing resolution. More precise of flight is found to lead to images with higher sphere contrast and lower background noise at each iteration, and convergent sphere contrast with fewer iterations. Combining these effects, the background noise at which each sphere reaches 90% of its final contrast is lower with improved timing resolution, with the amount of noise reduction underestimated by a conventional proportionality to the timing resolution.

UR - http://www.scopus.com/inward/record.url?scp=79960313938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960313938&partnerID=8YFLogxK

U2 - 10.1109/NSSMIC.2010.5874495

DO - 10.1109/NSSMIC.2010.5874495

M3 - Conference contribution

AN - SCOPUS:79960313938

SN - 9781424491063

T3 - IEEE Nuclear Science Symposium Conference Record

SP - 3657

EP - 3660

BT - IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010

T2 - 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010

Y2 - 30 October 2010 through 6 November 2010

ER -