TY - JOUR
T1 - Time of day affects episodic memory in older adults
AU - Martin, Barbara
AU - Buffington, Angela L.H.
AU - Welsh-Bohmer, Kathleen A.
AU - Brandt, Jason
N1 - Funding Information:
The authors wish to thank Suzanne Craft, Ph.D. and Patricia Boyle, Ph.D. for their many helpful and insightful comments about this manuscript. This work was supported by a cooperative agreement from the National Institute on Aging to the University of Washington, Seattle, Washington (U01AG15477). NIA collaborators participated in the design and conduct of the study. Naproxen sodium and matching placebo were supplied by Bayer Healthcare, and celecoxib and matching placebo were supplied by Pfizer, Inc. Dr Brandt receives royalties on sales of the Hopkins Verbal Learning Test–Revised.
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2008/3
Y1 - 2008/3
N2 - The neuropsychological test scores of 2,030 cognitively normal older adults were examined to evaluate performance patterns as they related to time of day (TOD) at which testing was initiated. Multiple regression analyses were used to examine the association of TOD with scores on seven neuropsychological tests used in the clinical evaluation of dementia. Episodic memory performance was significantly related to TOD, while memory span and verbal fluency were not. Best performance occurred during early morning hours and late afternoon; worst performance occurred mid-day (i.e., noon). These findings may have implications for clinical assessment, the design of research on dementia, and the daily functioning of older adults.
AB - The neuropsychological test scores of 2,030 cognitively normal older adults were examined to evaluate performance patterns as they related to time of day (TOD) at which testing was initiated. Multiple regression analyses were used to examine the association of TOD with scores on seven neuropsychological tests used in the clinical evaluation of dementia. Episodic memory performance was significantly related to TOD, while memory span and verbal fluency were not. Best performance occurred during early morning hours and late afternoon; worst performance occurred mid-day (i.e., noon). These findings may have implications for clinical assessment, the design of research on dementia, and the daily functioning of older adults.
KW - Aging
KW - Circadian rhythms
KW - Dementia
KW - Episodic memory
KW - Performance variability
UR - http://www.scopus.com/inward/record.url?scp=40349097934&partnerID=8YFLogxK
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U2 - 10.1080/13825580601186643
DO - 10.1080/13825580601186643
M3 - Article
C2 - 17851985
AN - SCOPUS:40349097934
SN - 1382-5585
VL - 15
SP - 146
EP - 164
JO - Aging, Neuropsychology, and Cognition
JF - Aging, Neuropsychology, and Cognition
IS - 2
ER -