Tempo entre o início dos sintomas e o tratamento de tuberculose pulmonar em um município com elevada incidência da doença

Translated title of the contribution: Time from symptom onset to the initiation of treatment of pulmonary tuberculosis in a city with a high incidence of the disease

Marina De Loureiro Maior, Renata Leborato Guerra, Michelle Cailleaux-Cezar, Jonathan E Golub, Marcus Barreto Conde

Research output: Contribution to journalArticle


Objective: To estimate the time elapsed between the onset of symptoms and the initiation of treatment of pulmonary tuberculosis among treatment-naïve patients with positive results in sputum smear microscopy, and to evaluate the variables associated with delays in diagnosis and in treatment initiation. Methods: This was a descriptive exploratory study involving 199 treatment-naïve tuberculosis patients ≥ 12 years of age with AFB-positive sputum smear microscopy results between 2006 and 2008. At their first (treatment initiation) visit to a primary health care clinic in the city of Nova Iguaçu, Brazil, the patients were interviewed and their ancillary test results were reviewed. Results: The medians (and respective interquartile ranges) of the time from symptom onset to the initiation of treatment of pulmonary tuberculosis, from symptom onset to seeking medical attention, from entry into care to diagnosis, and from entry into care to treatment initiation, in weeks, were 11 (6-24), 8 (4-20), 2 (1-8), and 1 (1-1), respectively. The variables gender, age, level of education, previous use of antibiotics, HIV status, site of first medical visit, and radiological extent of tuberculosis showed no associations with the time from entry into care to diagnosis or to treatment initiation. The main reason for the delay in seeking medical attention reported by the patients was their inability to recognize their symptoms as indicators of a disease. Conclusions: Among the patients studied, there was an unacceptably long delay between the onset of symptoms and the initiation of tuberculosis treatment.

Original languagePortuguese
Pages (from-to)202-209
Number of pages8
JournalJornal Brasileiro de Pneumologia
Issue number2
Publication statusPublished - Mar 2012



  • Delayed diagnosis
  • Tuberculosis/diagnosis
  • Tuberculosis/therapy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this