Time-dependent involvement of adult-born dentate granule cells in behavior

Woon Ryoung Kim, Kimberly Christian, Guo Li Ming, Hongjun Song

Research output: Contribution to journalArticle

Abstract

Adult-born neurons are continuously generated and incorporated into the circuitry of the hippocampus throughout life in mammals. Cumulative evidence supports a physiological role for adult-born neurons, yet it not clear whether this subset of dentate granule cells makes a unique contribution to hippocampal function. Perturbation or ablation of adult hippocampal neurogenesis leads to deficits in the acquisition of learned associations or memory recall, whereas an increase in adult hippocampal neurogenesis enhances some forms of learning and memory. The observed effects thus far appear to be task-dependent, species-specific, and sensitive to the timing of manipulations. Here, we review the recent evidence correlating adult-born dentate granule cells (DGCs) with hippocampal-dependent behavior and focus on the dynamic properties of this neuronal population that may underlie its function. We further discuss a framework for future investigations of how newly integrated neurons may contribute to hippocampal processing using advanced genetic techniques with enhanced temporal resolution.

Original languageEnglish (US)
Pages (from-to)470-479
Number of pages10
JournalBehavioural Brain Research
Volume227
Issue number2
DOIs
StatePublished - Feb 14 2012

Keywords

  • Adult neurogenesis
  • Behavior
  • Cognitive function
  • Dentate gyrus

ASJC Scopus subject areas

  • Behavioral Neuroscience

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