Time dependent entropy analysis of multiunit activity in the cortex following the hypoxic-ischemic brain injury

Shanbao Tong, Ming Chieh Ding, Nitish V. Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Previous study has shown that the scalp electrical activity (e.g. EEG) could provide information on hypoxic-ischemic (HI) brain injury. The time dependent entropy (TDE) of EEG was applied as a means to segment the injury and recovery phases. A reduction in entropy during the injury was explained as the result of the spiking or bursting activity during the recovery of HI injury. The aim of this study is to investigate the spiking activity in the cortex during (HI) brain injury. The multiunit activity recorded from the cortex (CTX MUA) is analyzed with TDE methods. The spike sensitive TDE tracks the electric activity at the cellular level. The CTX MUA has high TDE value after the HI injury, which gradually returns to the baseline level as the brain recovers. This is the first report of cellular electrical response to global ischemic injury.

Original languageEnglish (US)
Title of host publicationConference Proceedings - 1st International IEEE EMBS Conference on Neural Engineering
EditorsLaura J. Wolf, Jodi L. Strock
PublisherIEEE Computer Society
Pages368-371
Number of pages4
ISBN (Electronic)0780375793
DOIs
StatePublished - Jan 1 2003
Event1st International IEEE EMBS Conference on Neural Engineering - Capri Island, Italy
Duration: Mar 20 2003Mar 22 2003

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
Volume2003-January
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554

Other

Other1st International IEEE EMBS Conference on Neural Engineering
CountryItaly
CityCapri Island
Period3/20/033/22/03

Keywords

  • Asphyxia
  • Biomedical engineering
  • Brain injuries
  • Electroencephalography
  • Entropy
  • Microelectrodes
  • Monitoring
  • Neurons
  • Neurophysiology
  • Scalp

ASJC Scopus subject areas

  • Artificial Intelligence
  • Mechanical Engineering

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