Time course of alpha-1-acid glycoprotein and its relation to myocardial enzymes after acute myocardial infarction

Elsa Grace V. Giardina, Khether Raby, David Freilich, Joseph Vita, Rachel Brem, May Louie

Research output: Contribution to journalArticlepeer-review

Abstract

The acute phase reactant, alpha-1-acid glycoprotein, binds to a number of basic antiarrhythmic drugs, including lidocaine, quinidine, propranolol, imipramine and disopyramide. Binding to alpha-1-acid glycoprotein accounts for a decrease in free drug fraction and may alter the expected concentration: response relation of drugs particularly when there are unpredictably large or rapid changes in alpha-1-acid glycoprotein. To determine the time course and magnitude of alpha-1-acid glycoprotein for 1 month after acute myocardial infarction (AMI), blood samples were collected from 27 patients, 14 with AMI and 13 with a chest pain syndrome but no AMI. Patients with AMI had a significant increase in alpha-1-acid glycoprotein after 72 hours (mean 153 ± 35 mg/dl) (p < 0.05), and the maximum was observed on day 7 (mean 165 ± 53 mg/dl) (p < 0.05), returning to baseline by 28 days. There was no significant change in alpha-1-acid glycoprotein in patients with chest pain but no AMI. Regression analysis showed a significant relation between creatine kinase (p < 0.005) and lactic dehydrogenase (p < 0.001) vs alpha-1-acid glycoprotein indicating alpha-1-acid glycoprotein concentration is high in patients with large AMI. Changes in binding resulting from alpha-1-acid glycoprotein during AMI could account for misinterpretation of total drug concentration and response to antiarrhythmic drugs acutely, during convalescence and at discharge.

Original languageEnglish (US)
Pages (from-to)262-265
Number of pages4
JournalThe American journal of cardiology
Volume56
Issue number4
DOIs
StatePublished - Aug 1 1985

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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