Tics Following Methylphenidate Administration: A Report of 20 Cases

Martha Bridge Denckla; Jules R. Bemporad; Mary C. Mackay

doi:10.1001/jama.1976.03260390035024

Tics Following Methylphenidate Administration: A Report of 20 Cases

Martha Bridge Denckla, Jules R. Bemporad, Mary C. Mackay

Research output: Contribution to journal › Article

Abstract

Among children receiving methylphenidate hydrochloride, tics developed in 14, and in six children with pre-existing tics, the tics became worse. The clinical diagnosis in 19 cases was minimal brain dysfunction (MBD), and in one case, Gilles de la Tourette syndrome. Duration and dose of medication showed no particular pattern. In only one case did tics persist unchanged after methylphenidate treatment was discontinued. Tics related to methylphenidate administration appear to be rare (20 of 1,520 cases, or 1.3%) and may point to a specific susceptibility possibly related to personality profile (obsessive, perseverative, withdrawn).

Original language	English (US)
Pages (from-to)	1349-1351
Number of pages	3
Journal	JAMA: The Journal of the American Medical Association
Volume	235
Issue number	13
DOIs	https://doi.org/10.1001/jama.1976.03260390035024
State	Published - Mar 29 1976
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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Denckla, M. B., Bemporad, J. R., & Mackay, M. C. (1976). Tics Following Methylphenidate Administration: A Report of 20 Cases. JAMA: The Journal of the American Medical Association, 235(13), 1349-1351. https://doi.org/10.1001/jama.1976.03260390035024

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