TY - JOUR
T1 - Tics Following Methylphenidate Administration
T2 - A Report of 20 Cases
AU - Denckla, Martha Bridge
AU - Bemporad, Jules R.
AU - Mackay, Mary C.
PY - 1976/3/29
Y1 - 1976/3/29
N2 - Among children receiving methylphenidate hydrochloride, tics developed in 14, and in six children with pre-existing tics, the tics became worse. The clinical diagnosis in 19 cases was minimal brain dysfunction (MBD), and in one case, Gilles de la Tourette syndrome. Duration and dose of medication showed no particular pattern. In only one case did tics persist unchanged after methylphenidate treatment was discontinued. Tics related to methylphenidate administration appear to be rare (20 of 1,520 cases, or 1.3%) and may point to a specific susceptibility possibly related to personality profile (obsessive, perseverative, withdrawn).
AB - Among children receiving methylphenidate hydrochloride, tics developed in 14, and in six children with pre-existing tics, the tics became worse. The clinical diagnosis in 19 cases was minimal brain dysfunction (MBD), and in one case, Gilles de la Tourette syndrome. Duration and dose of medication showed no particular pattern. In only one case did tics persist unchanged after methylphenidate treatment was discontinued. Tics related to methylphenidate administration appear to be rare (20 of 1,520 cases, or 1.3%) and may point to a specific susceptibility possibly related to personality profile (obsessive, perseverative, withdrawn).
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U2 - 10.1001/jama.1976.03260390035024
DO - 10.1001/jama.1976.03260390035024
M3 - Article
C2 - 1061848
AN - SCOPUS:0017317786
VL - 235
SP - 1349
EP - 1351
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
SN - 0098-7484
IS - 13
ER -