Thyrotropin response to thyrotropin-releasing hormone in patients with dementia of the Alzheimer type

Marilyn Albert, Michael Jenike, Ralph Nixon, Kenneth Nobel

Research output: Contribution to journalArticlepeer-review

Abstract

Eleven patients with senile dementia of the Alzheimer type and 11 age-matched control subjects were given the thyrotropin-releasing hormone (TRH) test. The two groups did not differ with respect to peak thyrotropin (TSH) response or TSH levels at baseline, 20, 30, and 45 min after TRH injection. There were significant differences between the groups on Hamilton Depression Rating Scale scores (p < 0.03), although neither group met clinical criteria for depression. Items that were significantly different pertained to depressed mood, loss of interest, loss of insight, suicidal ideation, and obsessional symptoms.

Original languageEnglish (US)
Pages (from-to)267-271
Number of pages5
JournalBiological psychiatry
Volume33
Issue number4
DOIs
StatePublished - Feb 15 1993
Externally publishedYes

Keywords

  • Alzheimer's disease
  • TRH
  • depression

ASJC Scopus subject areas

  • Biological Psychiatry

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