Thyroid tumorigenesis and molecular markers in thyroid cancer

Guennadi Kouniavsky; Martha A. Zeiger

doi:10.1097/CCO.0b013e328333846f

Thyroid tumorigenesis and molecular markers in thyroid cancer

Guennadi Kouniavsky, Martha A. Zeiger

School of Medicine

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Purpose of review The purpose of this review is to provide an update on recent advances in the understanding of thyroid cancer tumorigensis and implications in clinical practice. Recent findings: Recent novel and promising findings include additional abnormalities in key pathways associated with thyroid tumorigenesis (RET-Ras-BRAF-MEK; RET-β-cateinin; TRK-PI3K-AKT; and MDM-p53-PTEN), single-nucleotide polymorphisms associated with thyroid cancer susceptibility, epigenetic silencing, alternative splicing, and gene expression abnormalities. Complex regulatory mechanisms and insights into ways in which molecular aberrancies occur are becoming better understood through this research. Summary: With ongoing research, clinical problems such as the suspicious thyroid fine needle aspiration, better treatment algorithms for well differentiated thyroid cancer, and more effective treatment for anaplastic cancer will likely be found.

Original language	English (US)
Pages (from-to)	23-29
Number of pages	7
Journal	Current opinion in oncology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1097/CCO.0b013e328333846f
State	Published - Jan 2010

Keywords

Alternative splicing
Gene rearrangement
Molecular abnormalities
Single-nucleotide polymorphisms
Thyroid tumorigenesis

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1097/CCO.0b013e328333846f

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AB - Purpose of review The purpose of this review is to provide an update on recent advances in the understanding of thyroid cancer tumorigensis and implications in clinical practice. Recent findings: Recent novel and promising findings include additional abnormalities in key pathways associated with thyroid tumorigenesis (RET-Ras-BRAF-MEK; RET-β-cateinin; TRK-PI3K-AKT; and MDM-p53-PTEN), single-nucleotide polymorphisms associated with thyroid cancer susceptibility, epigenetic silencing, alternative splicing, and gene expression abnormalities. Complex regulatory mechanisms and insights into ways in which molecular aberrancies occur are becoming better understood through this research. Summary: With ongoing research, clinical problems such as the suspicious thyroid fine needle aspiration, better treatment algorithms for well differentiated thyroid cancer, and more effective treatment for anaplastic cancer will likely be found.

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Thyroid tumorigenesis and molecular markers in thyroid cancer

Abstract

Keywords

ASJC Scopus subject areas

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