Thyroid tumorigenesis and molecular markers in thyroid cancer

Guennadi Kouniavsky, Martha A. Zeiger

Research output: Contribution to journalReview article

Abstract

Purpose of review The purpose of this review is to provide an update on recent advances in the understanding of thyroid cancer tumorigensis and implications in clinical practice. Recent findings: Recent novel and promising findings include additional abnormalities in key pathways associated with thyroid tumorigenesis (RET-Ras-BRAF-MEK; RET-β-cateinin; TRK-PI3K-AKT; and MDM-p53-PTEN), single-nucleotide polymorphisms associated with thyroid cancer susceptibility, epigenetic silencing, alternative splicing, and gene expression abnormalities. Complex regulatory mechanisms and insights into ways in which molecular aberrancies occur are becoming better understood through this research. Summary: With ongoing research, clinical problems such as the suspicious thyroid fine needle aspiration, better treatment algorithms for well differentiated thyroid cancer, and more effective treatment for anaplastic cancer will likely be found.

Original languageEnglish (US)
Pages (from-to)23-29
Number of pages7
JournalCurrent opinion in oncology
Volume22
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • Alternative splicing
  • Gene rearrangement
  • Molecular abnormalities
  • Single-nucleotide polymorphisms
  • Thyroid tumorigenesis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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