Thyroid-Specific Autoantibodies Studied by Passive Cutaneous Anaphylaxis of Guinea Pig

Zoltan Ovary; Harry Randall; Ernest Witebsky; Noel R. Rose; Sidney Shulman; Richard Metzgar

doi:10.3181/00379727-99-24363

Thyroid-Specific Autoantibodies Studied by Passive Cutaneous Anaphylaxis of Guinea Pig

Zoltan Ovary, Harry Randall, Ernest Witebsky, Noel R. Rose, Sidney Shulman, Richard Metzgar

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

1. Passive cutaneous anaphylaxis of the guinea pig has been successfully used to study thyroid autoantibodies of rabbit, guinea pig, and man. 2. The thyroid autoantibody proved to be specific for the homologous antigen (thyroid extract and purified derivative) and did not give cross reactions with thyroid extracts of other species. 3. Five human sera with high titer of thyroid autoantibody were studied. The antibody was completely neutralized by human thyroid extract or human thyroglobulin, but was not significantly affected by any of a variety of other organ extracts or of iodinated amino acids, again indicating the specificity of this type of antibody.

Original language	English (US)
Pages (from-to)	397-401
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	99
Issue number	2
DOIs	https://doi.org/10.3181/00379727-99-24363
State	Published - Nov 1958

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Thyroid-Specific Autoantibodies Studied by Passive Cutaneous Anaphylaxis of Guinea Pig",

abstract = "1. Passive cutaneous anaphylaxis of the guinea pig has been successfully used to study thyroid autoantibodies of rabbit, guinea pig, and man. 2. The thyroid autoantibody proved to be specific for the homologous antigen (thyroid extract and purified derivative) and did not give cross reactions with thyroid extracts of other species. 3. Five human sera with high titer of thyroid autoantibody were studied. The antibody was completely neutralized by human thyroid extract or human thyroglobulin, but was not significantly affected by any of a variety of other organ extracts or of iodinated amino acids, again indicating the specificity of this type of antibody.",

author = "Zoltan Ovary and Harry Randall and Ernest Witebsky and Rose, {Noel R.} and Sidney Shulman and Richard Metzgar",

note = "Funding Information: This work was supported in part by the sponsorship of the Comm. on Cutaneous Diseases, Armed Forces Epidemiological Board, and of the Office of the Surgeon General, and in part by a Research Grant, from the Nat. Cancer Inst., P.H.S. (C-2357). ",

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AU - Ovary, Zoltan

AU - Randall, Harry

AU - Witebsky, Ernest

AU - Rose, Noel R.

AU - Shulman, Sidney

AU - Metzgar, Richard

N1 - Funding Information: This work was supported in part by the sponsorship of the Comm. on Cutaneous Diseases, Armed Forces Epidemiological Board, and of the Office of the Surgeon General, and in part by a Research Grant, from the Nat. Cancer Inst., P.H.S. (C-2357).

PY - 1958/11

Y1 - 1958/11

N2 - 1. Passive cutaneous anaphylaxis of the guinea pig has been successfully used to study thyroid autoantibodies of rabbit, guinea pig, and man. 2. The thyroid autoantibody proved to be specific for the homologous antigen (thyroid extract and purified derivative) and did not give cross reactions with thyroid extracts of other species. 3. Five human sera with high titer of thyroid autoantibody were studied. The antibody was completely neutralized by human thyroid extract or human thyroglobulin, but was not significantly affected by any of a variety of other organ extracts or of iodinated amino acids, again indicating the specificity of this type of antibody.

AB - 1. Passive cutaneous anaphylaxis of the guinea pig has been successfully used to study thyroid autoantibodies of rabbit, guinea pig, and man. 2. The thyroid autoantibody proved to be specific for the homologous antigen (thyroid extract and purified derivative) and did not give cross reactions with thyroid extracts of other species. 3. Five human sera with high titer of thyroid autoantibody were studied. The antibody was completely neutralized by human thyroid extract or human thyroglobulin, but was not significantly affected by any of a variety of other organ extracts or of iodinated amino acids, again indicating the specificity of this type of antibody.

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Thyroid-Specific Autoantibodies Studied by Passive Cutaneous Anaphylaxis of Guinea Pig

Abstract

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