Thyroid-Specific Autoantibodies Studied by Passive Cutaneous Anaphylaxis of Guinea Pig

Zoltan Ovary, Harry Randall, Ernest Witebsky, Noel R. Rose, Sidney Shulman, Richard Metzgar

Research output: Contribution to journalArticlepeer-review

Abstract

1. Passive cutaneous anaphylaxis of the guinea pig has been successfully used to study thyroid autoantibodies of rabbit, guinea pig, and man. 2. The thyroid autoantibody proved to be specific for the homologous antigen (thyroid extract and purified derivative) and did not give cross reactions with thyroid extracts of other species. 3. Five human sera with high titer of thyroid autoantibody were studied. The antibody was completely neutralized by human thyroid extract or human thyroglobulin, but was not significantly affected by any of a variety of other organ extracts or of iodinated amino acids, again indicating the specificity of this type of antibody.

Original languageEnglish (US)
Pages (from-to)397-401
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
Volume99
Issue number2
DOIs
StatePublished - 1958

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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