Thyroid Hormone Suppression Therapy

Bernadette Biondi, David S Cooper

Research output: Contribution to journalArticle

Abstract

Thyroid hormone suppression therapy is designed to lower serum thyrotropin (TSH) levels using doses of thyroid hormone in excess of what would normally be required to maintain a euthyroid state. The basis of this therapy is the knowledge that TSH is a growth factor for thyroid cancer, so that lower serum TSH levels might be associated with decreased disease activity. However, clinical studies have not documented improved outcomes with TSH suppression, except in patients with the most advanced disease. Furthermore, there are a number of negative outcomes related to aggressive thyroid hormone therapy, including osteoporosis, fracture, and cardiovascular disease. Therefore, a graded approach to TSH suppression is recommended by the American Thyroid Association, based on initial risk and ongoing risk assessment.

Original languageEnglish (US)
JournalEndocrinology and Metabolism Clinics of North America
DOIs
StateAccepted/In press - Jan 1 2018

    Fingerprint

Keywords

  • Bone
  • Cardiovascular system
  • Levothyroxine
  • Mortality
  • Thyroid cancer
  • Thyrotropin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this