Thyroid hormone regulation of central nervous system (CNS) beta-endorphin and ACTH

S. R. Gambert, T. L. Garthwaite, C. H. Pontzer, T. C. Hagen

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Several observations suggest a relationship between thyroid hormone and the endogenous opiates, enkephalins and endorphin. Morphine (Shahid-Salles and Donovan 1977) and leucine-enkephalin (May, Mittler, Manougian and Ertel 1979) blunt TSH response to TRH in vivo. TRH overcomes the CNS depressant effects of beta-endorphin (Collu, Tache and Lis 1977). In addition, thyroid hormone can modify CNS levels of beta-endorphin (Panerai, Lee and Bellabarba 1979). Since CNS beta-endorphin and ACTH are derived from a common precursor (Mains, Eipper and Ling 1977), we studied the role of thyroid hormone in the regulation of both of these peptides.

Original languageEnglish (US)
Pages (from-to)345-346
Number of pages2
JournalHormone and Metabolic Research
Issue number7
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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