Thyroid function and thyroid autoimmunity independently modulate serum concentration of soluble interleukin 2 (IL-2) receptor (sIL-2R) in thyroid disease

S. Mariotti, Patrizio P Caturegli, G. Barbesino, M. Marino, G. F. Del Prete, L. Chiovato, M. Tonacchera, M. De Carli, A. Pinchera

Research output: Contribution to journalArticle

Abstract

Objective. The serum concentration of soluble interleukin-2 receptor (sIL-2R) is a marker of T-lymphocyte activation. Increased circulating sIL-2R has been reported in untreated Graves' disease. This finding has been interpreted as the consequence of the autoimmune activation, but recent data suggest that sIL-2R is directly correlated to thyroid state. The aim of this study was to elucidate the respective roles of autoimmunity and thyroid function in modulating serum sIL-2R. Design and patients. sIL-2R was evaluated in 20 normal euthyroid subjects and in a large series of patients with autoimmune and non-autoimmune thyroid disorders in different functional state. Measurements. sIL-2R was assayed by a solid-phase monoclonal antibody assisted ELISA method. Results. Serum sIL-2R in normals was 461 ± 186 U/ml (mean ± SD). Increased sIL-2R was found in 61 hyperthyroid patients with Graves' disease (1610 ± 962 U/ml, P <0.0001) and in 23 with toxic adenoma (1121 ± 598 U/ml, P <0.0001). Restoration of euthyroidism lowered to normal sIL-2R in both groups. Serum sIL-2R was higher in euthyroid Graves' disease patients with active than in those with non-active ophthalmopathy. Decreased serum sIL-2R (228 ± 93 U/ml, P <0.0001) was found in 30 patients hypothyroid after total thyroidectomy. Highly variable circulating sIL-2R (range 100-1456 U/ml, mean ± SD: 379 ± 301 U/ml) was found in 49 patients with hypothyroid Hashimoto's thyroiditis (P = NS vs normals; P <0.02 vs post-thyroidectomy hypothyroid patients). Treatment with L-thyroxine increased sIL-2R in all thyroidectomized and in the majority of Hashimoto's thyroiditis patients. In individual Hashimoto's thyroiditis patients (mostly with increased serum sIL-2R), L-thyroxine caused a decrease of circulating sIL-2R. sIL-2R was normal in 29 patients with euthyroid Hashmoto's thyroiditis. Both in Graves' disease and in Hashimoto's thyroiditis, no correlation was found between sIL-2R and anti-thyroglobulin, anti-thyroid peroxidase and anti-thyrotrophin-receptor autoantibodies. Highly significant positive correlation between serum thyroid hormones and sIL-2R was found in all study groups. Conclusions. In thyroid disorders thyroid hormones are the main regulator of serum sIL-2R concentration. The contribution of autoimmune activation may be detected only in some patients with autoimmune hypothyroidism, while in Graves' disease the role of the immune system is masked by the hyperthyroid state.

Original languageEnglish (US)
Pages (from-to)415-422
Number of pages8
JournalClinical Endocrinology
Volume37
Issue number5
StatePublished - 1992
Externally publishedYes

Fingerprint

Interleukin-2 Receptors
Thyroid Diseases
Autoimmunity
Interleukin-2
Thyroid Gland
Serum
Graves Disease
Hashimoto Disease
Thyroidectomy
Hyperthyroidism
Thyroxine
Thyroid Hormones
Thyroiditis
Iodide Peroxidase
Poisons
Immune System Diseases

ASJC Scopus subject areas

  • Endocrinology

Cite this

Thyroid function and thyroid autoimmunity independently modulate serum concentration of soluble interleukin 2 (IL-2) receptor (sIL-2R) in thyroid disease. / Mariotti, S.; Caturegli, Patrizio P; Barbesino, G.; Marino, M.; Del Prete, G. F.; Chiovato, L.; Tonacchera, M.; De Carli, M.; Pinchera, A.

In: Clinical Endocrinology, Vol. 37, No. 5, 1992, p. 415-422.

Research output: Contribution to journalArticle

Mariotti, S, Caturegli, PP, Barbesino, G, Marino, M, Del Prete, GF, Chiovato, L, Tonacchera, M, De Carli, M & Pinchera, A 1992, 'Thyroid function and thyroid autoimmunity independently modulate serum concentration of soluble interleukin 2 (IL-2) receptor (sIL-2R) in thyroid disease', Clinical Endocrinology, vol. 37, no. 5, pp. 415-422.
Mariotti, S. ; Caturegli, Patrizio P ; Barbesino, G. ; Marino, M. ; Del Prete, G. F. ; Chiovato, L. ; Tonacchera, M. ; De Carli, M. ; Pinchera, A. / Thyroid function and thyroid autoimmunity independently modulate serum concentration of soluble interleukin 2 (IL-2) receptor (sIL-2R) in thyroid disease. In: Clinical Endocrinology. 1992 ; Vol. 37, No. 5. pp. 415-422.
@article{08bda209e4834c9694a8396f1a24a32c,
title = "Thyroid function and thyroid autoimmunity independently modulate serum concentration of soluble interleukin 2 (IL-2) receptor (sIL-2R) in thyroid disease",
abstract = "Objective. The serum concentration of soluble interleukin-2 receptor (sIL-2R) is a marker of T-lymphocyte activation. Increased circulating sIL-2R has been reported in untreated Graves' disease. This finding has been interpreted as the consequence of the autoimmune activation, but recent data suggest that sIL-2R is directly correlated to thyroid state. The aim of this study was to elucidate the respective roles of autoimmunity and thyroid function in modulating serum sIL-2R. Design and patients. sIL-2R was evaluated in 20 normal euthyroid subjects and in a large series of patients with autoimmune and non-autoimmune thyroid disorders in different functional state. Measurements. sIL-2R was assayed by a solid-phase monoclonal antibody assisted ELISA method. Results. Serum sIL-2R in normals was 461 ± 186 U/ml (mean ± SD). Increased sIL-2R was found in 61 hyperthyroid patients with Graves' disease (1610 ± 962 U/ml, P <0.0001) and in 23 with toxic adenoma (1121 ± 598 U/ml, P <0.0001). Restoration of euthyroidism lowered to normal sIL-2R in both groups. Serum sIL-2R was higher in euthyroid Graves' disease patients with active than in those with non-active ophthalmopathy. Decreased serum sIL-2R (228 ± 93 U/ml, P <0.0001) was found in 30 patients hypothyroid after total thyroidectomy. Highly variable circulating sIL-2R (range 100-1456 U/ml, mean ± SD: 379 ± 301 U/ml) was found in 49 patients with hypothyroid Hashimoto's thyroiditis (P = NS vs normals; P <0.02 vs post-thyroidectomy hypothyroid patients). Treatment with L-thyroxine increased sIL-2R in all thyroidectomized and in the majority of Hashimoto's thyroiditis patients. In individual Hashimoto's thyroiditis patients (mostly with increased serum sIL-2R), L-thyroxine caused a decrease of circulating sIL-2R. sIL-2R was normal in 29 patients with euthyroid Hashmoto's thyroiditis. Both in Graves' disease and in Hashimoto's thyroiditis, no correlation was found between sIL-2R and anti-thyroglobulin, anti-thyroid peroxidase and anti-thyrotrophin-receptor autoantibodies. Highly significant positive correlation between serum thyroid hormones and sIL-2R was found in all study groups. Conclusions. In thyroid disorders thyroid hormones are the main regulator of serum sIL-2R concentration. The contribution of autoimmune activation may be detected only in some patients with autoimmune hypothyroidism, while in Graves' disease the role of the immune system is masked by the hyperthyroid state.",
author = "S. Mariotti and Caturegli, {Patrizio P} and G. Barbesino and M. Marino and {Del Prete}, {G. F.} and L. Chiovato and M. Tonacchera and {De Carli}, M. and A. Pinchera",
year = "1992",
language = "English (US)",
volume = "37",
pages = "415--422",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Thyroid function and thyroid autoimmunity independently modulate serum concentration of soluble interleukin 2 (IL-2) receptor (sIL-2R) in thyroid disease

AU - Mariotti, S.

AU - Caturegli, Patrizio P

AU - Barbesino, G.

AU - Marino, M.

AU - Del Prete, G. F.

AU - Chiovato, L.

AU - Tonacchera, M.

AU - De Carli, M.

AU - Pinchera, A.

PY - 1992

Y1 - 1992

N2 - Objective. The serum concentration of soluble interleukin-2 receptor (sIL-2R) is a marker of T-lymphocyte activation. Increased circulating sIL-2R has been reported in untreated Graves' disease. This finding has been interpreted as the consequence of the autoimmune activation, but recent data suggest that sIL-2R is directly correlated to thyroid state. The aim of this study was to elucidate the respective roles of autoimmunity and thyroid function in modulating serum sIL-2R. Design and patients. sIL-2R was evaluated in 20 normal euthyroid subjects and in a large series of patients with autoimmune and non-autoimmune thyroid disorders in different functional state. Measurements. sIL-2R was assayed by a solid-phase monoclonal antibody assisted ELISA method. Results. Serum sIL-2R in normals was 461 ± 186 U/ml (mean ± SD). Increased sIL-2R was found in 61 hyperthyroid patients with Graves' disease (1610 ± 962 U/ml, P <0.0001) and in 23 with toxic adenoma (1121 ± 598 U/ml, P <0.0001). Restoration of euthyroidism lowered to normal sIL-2R in both groups. Serum sIL-2R was higher in euthyroid Graves' disease patients with active than in those with non-active ophthalmopathy. Decreased serum sIL-2R (228 ± 93 U/ml, P <0.0001) was found in 30 patients hypothyroid after total thyroidectomy. Highly variable circulating sIL-2R (range 100-1456 U/ml, mean ± SD: 379 ± 301 U/ml) was found in 49 patients with hypothyroid Hashimoto's thyroiditis (P = NS vs normals; P <0.02 vs post-thyroidectomy hypothyroid patients). Treatment with L-thyroxine increased sIL-2R in all thyroidectomized and in the majority of Hashimoto's thyroiditis patients. In individual Hashimoto's thyroiditis patients (mostly with increased serum sIL-2R), L-thyroxine caused a decrease of circulating sIL-2R. sIL-2R was normal in 29 patients with euthyroid Hashmoto's thyroiditis. Both in Graves' disease and in Hashimoto's thyroiditis, no correlation was found between sIL-2R and anti-thyroglobulin, anti-thyroid peroxidase and anti-thyrotrophin-receptor autoantibodies. Highly significant positive correlation between serum thyroid hormones and sIL-2R was found in all study groups. Conclusions. In thyroid disorders thyroid hormones are the main regulator of serum sIL-2R concentration. The contribution of autoimmune activation may be detected only in some patients with autoimmune hypothyroidism, while in Graves' disease the role of the immune system is masked by the hyperthyroid state.

AB - Objective. The serum concentration of soluble interleukin-2 receptor (sIL-2R) is a marker of T-lymphocyte activation. Increased circulating sIL-2R has been reported in untreated Graves' disease. This finding has been interpreted as the consequence of the autoimmune activation, but recent data suggest that sIL-2R is directly correlated to thyroid state. The aim of this study was to elucidate the respective roles of autoimmunity and thyroid function in modulating serum sIL-2R. Design and patients. sIL-2R was evaluated in 20 normal euthyroid subjects and in a large series of patients with autoimmune and non-autoimmune thyroid disorders in different functional state. Measurements. sIL-2R was assayed by a solid-phase monoclonal antibody assisted ELISA method. Results. Serum sIL-2R in normals was 461 ± 186 U/ml (mean ± SD). Increased sIL-2R was found in 61 hyperthyroid patients with Graves' disease (1610 ± 962 U/ml, P <0.0001) and in 23 with toxic adenoma (1121 ± 598 U/ml, P <0.0001). Restoration of euthyroidism lowered to normal sIL-2R in both groups. Serum sIL-2R was higher in euthyroid Graves' disease patients with active than in those with non-active ophthalmopathy. Decreased serum sIL-2R (228 ± 93 U/ml, P <0.0001) was found in 30 patients hypothyroid after total thyroidectomy. Highly variable circulating sIL-2R (range 100-1456 U/ml, mean ± SD: 379 ± 301 U/ml) was found in 49 patients with hypothyroid Hashimoto's thyroiditis (P = NS vs normals; P <0.02 vs post-thyroidectomy hypothyroid patients). Treatment with L-thyroxine increased sIL-2R in all thyroidectomized and in the majority of Hashimoto's thyroiditis patients. In individual Hashimoto's thyroiditis patients (mostly with increased serum sIL-2R), L-thyroxine caused a decrease of circulating sIL-2R. sIL-2R was normal in 29 patients with euthyroid Hashmoto's thyroiditis. Both in Graves' disease and in Hashimoto's thyroiditis, no correlation was found between sIL-2R and anti-thyroglobulin, anti-thyroid peroxidase and anti-thyrotrophin-receptor autoantibodies. Highly significant positive correlation between serum thyroid hormones and sIL-2R was found in all study groups. Conclusions. In thyroid disorders thyroid hormones are the main regulator of serum sIL-2R concentration. The contribution of autoimmune activation may be detected only in some patients with autoimmune hypothyroidism, while in Graves' disease the role of the immune system is masked by the hyperthyroid state.

UR - http://www.scopus.com/inward/record.url?scp=0026671399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026671399&partnerID=8YFLogxK

M3 - Article

C2 - 1486691

AN - SCOPUS:0026671399

VL - 37

SP - 415

EP - 422

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 5

ER -