Thyroid cell MHC class II antigens

a perspective on the aetiology of autoimmune thyroid disease.

T. F. Davies, Sheila H. Roman, W. A. Mackenzie, N. Goldsmith, S. M. Dower, L. A. Piccinini

Research output: Contribution to journalArticle

Abstract

An association exists between certain MHC polymorphisms and autoimmune thyroid disease in animals and humans. The observation of MHC class II antigen expression by the thyroid suggests that such associations may have mechanistic explanations at the level of the thyroid cell. Such class II antigen expression, rather than being a constitutive property of thyroid epithelium, appears to be primarily mediated by lymphokine secretion from intrathyroidal T lymphocytes and a variety of agents, for example TSh and TSH receptor antibodies, may amplify such lymphokine action. Thyroid cell class II antigens participate in activation and amplification of T cells and are involved in presentation of thyroid antigen to the immune system. The relationship between these local immune interactions and the initial events leading to the development of autoimmune thyroid disease requires a more fundamental understanding of the workings of the immune system at the site of antigenic stimulation.

Original languageEnglish (US)
Pages (from-to)13-20
Number of pages8
JournalActa Endocrinologica, Supplement
Volume281
StatePublished - 1987
Externally publishedYes

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Histocompatibility Antigens Class II
Thyroid Diseases
Autoimmune Diseases
Thyroid Gland
Lymphokines
Immune System
T-Lymphocytes
Antigen Presentation
Epithelium
Observation

ASJC Scopus subject areas

  • Endocrinology

Cite this

Davies, T. F., Roman, S. H., Mackenzie, W. A., Goldsmith, N., Dower, S. M., & Piccinini, L. A. (1987). Thyroid cell MHC class II antigens: a perspective on the aetiology of autoimmune thyroid disease. Acta Endocrinologica, Supplement, 281, 13-20.

Thyroid cell MHC class II antigens : a perspective on the aetiology of autoimmune thyroid disease. / Davies, T. F.; Roman, Sheila H.; Mackenzie, W. A.; Goldsmith, N.; Dower, S. M.; Piccinini, L. A.

In: Acta Endocrinologica, Supplement, Vol. 281, 1987, p. 13-20.

Research output: Contribution to journalArticle

Davies, TF, Roman, SH, Mackenzie, WA, Goldsmith, N, Dower, SM & Piccinini, LA 1987, 'Thyroid cell MHC class II antigens: a perspective on the aetiology of autoimmune thyroid disease.', Acta Endocrinologica, Supplement, vol. 281, pp. 13-20.
Davies, T. F. ; Roman, Sheila H. ; Mackenzie, W. A. ; Goldsmith, N. ; Dower, S. M. ; Piccinini, L. A. / Thyroid cell MHC class II antigens : a perspective on the aetiology of autoimmune thyroid disease. In: Acta Endocrinologica, Supplement. 1987 ; Vol. 281. pp. 13-20.
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