Thyroid cancer histological subtypes based on tumor size: National perspective

Zaid Al-Qurayshi; Megan J. Foggia; Nitin Pagedar; Grace S. Lee; Ralph Tufano; Emad Kandil

doi:10.1002/hed.26159

Thyroid cancer histological subtypes based on tumor size: National perspective

Zaid Al-Qurayshi, Megan J. Foggia, Nitin Pagedar, Grace S. Lee, Ralph Tufano, Emad Kandil

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: Thyroid tumor size is an important prognostic factor. The aim of this study is to examine the histological subtypes and management of thyroid cancer based on tumor size (≤4 cm vs >4 cm). Methods: Retrospective cohort study utilizing the National Cancer Database, 2004-2014. Results: A total of 152 387 patients were included, 13 614 (8.9%) of whom had a tumor size >4 cm. Histological subtypes of tumors >4 cm were: 69.6% papillary thyroid carcinoma, 17.5% FTC, 7.9% HCC, and 2.8% medullary thyroid carcinoma (MTC). High-volume hospitals for thyroid surgery were less likely to perform two-stage thyroidectomy, particularly for tumors ≤4 cm. Low-volume hospitals had a higher risk of staged thyroidectomy for MTC ≤4 cm (19.8%) compared with high-volume hospitals (8.7%) (P <.001). Conclusions: This study describes the prevalence of thyroid cancer subtypes. In the era of a conservative approach to differentiated thyroid carcinoma, there could be a potential increase in the risk of staged thyroidectomy.

Original language	English (US)
Pages (from-to)	2257-2266
Number of pages	10
Journal	Head and Neck
Volume	42
Issue number	9
DOIs	https://doi.org/10.1002/hed.26159
State	Published - Sep 1 2020

Keywords

hospital volume
medullary thyroid carcinoma
thyroid cancer
thyroid surgery
tumor size

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.26159

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title = "Thyroid cancer histological subtypes based on tumor size: National perspective",

abstract = "Background: Thyroid tumor size is an important prognostic factor. The aim of this study is to examine the histological subtypes and management of thyroid cancer based on tumor size (≤4 cm vs >4 cm). Methods: Retrospective cohort study utilizing the National Cancer Database, 2004-2014. Results: A total of 152 387 patients were included, 13 614 (8.9%) of whom had a tumor size >4 cm. Histological subtypes of tumors >4 cm were: 69.6% papillary thyroid carcinoma, 17.5% FTC, 7.9% HCC, and 2.8% medullary thyroid carcinoma (MTC). High-volume hospitals for thyroid surgery were less likely to perform two-stage thyroidectomy, particularly for tumors ≤4 cm. Low-volume hospitals had a higher risk of staged thyroidectomy for MTC ≤4 cm (19.8%) compared with high-volume hospitals (8.7%) (P <.001). Conclusions: This study describes the prevalence of thyroid cancer subtypes. In the era of a conservative approach to differentiated thyroid carcinoma, there could be a potential increase in the risk of staged thyroidectomy.",

keywords = "hospital volume, medullary thyroid carcinoma, thyroid cancer, thyroid surgery, tumor size",

author = "Zaid Al-Qurayshi and Foggia, {Megan J.} and Nitin Pagedar and Lee, {Grace S.} and Ralph Tufano and Emad Kandil",

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AU - Tufano, Ralph

AU - Kandil, Emad

N1 - Funding Information: Z. A.‐Q. and M. J. F. are supported by the National Institutes of Health—Institutional National Research Award: T32 (#5T32DC000040). Publisher Copyright: © 2020 Wiley Periodicals, Inc.

PY - 2020/9/1

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N2 - Background: Thyroid tumor size is an important prognostic factor. The aim of this study is to examine the histological subtypes and management of thyroid cancer based on tumor size (≤4 cm vs >4 cm). Methods: Retrospective cohort study utilizing the National Cancer Database, 2004-2014. Results: A total of 152 387 patients were included, 13 614 (8.9%) of whom had a tumor size >4 cm. Histological subtypes of tumors >4 cm were: 69.6% papillary thyroid carcinoma, 17.5% FTC, 7.9% HCC, and 2.8% medullary thyroid carcinoma (MTC). High-volume hospitals for thyroid surgery were less likely to perform two-stage thyroidectomy, particularly for tumors ≤4 cm. Low-volume hospitals had a higher risk of staged thyroidectomy for MTC ≤4 cm (19.8%) compared with high-volume hospitals (8.7%) (P <.001). Conclusions: This study describes the prevalence of thyroid cancer subtypes. In the era of a conservative approach to differentiated thyroid carcinoma, there could be a potential increase in the risk of staged thyroidectomy.

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Thyroid cancer histological subtypes based on tumor size: National perspective

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