Thyroglobulin measurements in fine-needle aspiration cytology of lymph nodes for the detection of metastatic papillary thyroid carcinoma

Qing Kay Li, Summer L. Nugent, Joely Straseski, David S Cooper, Stefan Riedel, Frederic B Askin, Lori J Sokoll

Research output: Contribution to journalArticle


BACKGROUND: Ultrasound-guided fine-needle aspiration (US-FNA) cytology is a commonly used method in the surveillance of suspicious lymph nodes (LNs) in patients with papillary thyroid carcinoma (PTC). The measurement of thyroglobulin (Tg) levels in LNs during FNA has been suggested to improve the diagnosis. In the current study, the use of US-FNA-Tg in LNs that were suspicious for metastatic PTC was investigated. METHODS: A total of 208 cases from the Johns Hopkins Hospital with both US-guided FNA cytology and US-FNA-Tg measurements were included; 60 cases had follow-up surgeries performed. Tg levels were correlated with cytological and histological diagnoses. RESULTS: Of 35 cases of cytologically diagnosed metastatic PTC, 34 were confirmed by surgery. The median US-FNA-Tg concentration was 4232.7 ng/mL, whereas in 112 benign LNs the median Tg concentration was

Original languageEnglish (US)
Pages (from-to)440-448
Number of pages9
JournalCancer cytopathology
Issue number8
StatePublished - Aug 2013



  • Cytology
  • Fine-needle aspiration
  • Fine-needle aspiration thyroglobulin level
  • Lymph node metastasis
  • Papillary thyroid carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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