Thymic selection

Drew Pardoll, Ana Carrera

Research output: Contribution to journalArticlepeer-review

Abstract

The ability of T celss to recognize foreign antigens, distinguish them from self antigens, and regulate immune responses depends largely on which of the vast array of different T-cell receptors they display on their surface, the so called T-cell repertoire. Two selection processes, positive and negative selection, operate on developing T cells and allow only a subset of all possible T cells to differentiate. New developments in transgenic mouse technology and the study of T-cell signalling are unravelling these fascinating processes.

Original languageEnglish (US)
Pages (from-to)162-165
Number of pages4
JournalCurrent Opinion in Immunology
Volume4
Issue number2
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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