Thymic function in HIV infection.

Rohan Hazra, Crystal Mackall

Research output: Contribution to journalArticle

Abstract

Current models hold that CD4+ depletion occurs as a result of direct and indirect effects of HIV, which both kill peripheral CD4+ cells and prevent adequate regeneration. Although age-associated involution diminishes thymic reserve and HIV is clearly thymotoxic, clinical trials have nonetheless shown that large proportions of patients who sustain adequate control of viral replication with highly active antiretroviral therapy (HAART) will demonstrate some evidence for thymic-dependent immune reconstitution, which is associated with improved immune competence. Furthermore, patients with insufficient or absent immune reconstitution following HAART generally lack evidence for thymopoiesis. Current studies are focused on improving our understanding of the causes for thymic failure in HIV infection. Recent work has demonstrated that some HIV strains, especially those that are CXCR4 trophic, are more thymotoxic and may contribute to irreversible thymic damage in this population.

Original languageEnglish (US)
Pages (from-to)24-28
Number of pages5
JournalClinical Advances in Hematology and Oncology
Volume2
Issue number1
StatePublished - Feb 2005
Externally publishedYes

Fingerprint

HIV Infections
Highly Active Antiretroviral Therapy
HIV
Mental Competency
Regeneration
Clinical Trials
Population

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Thymic function in HIV infection. / Hazra, Rohan; Mackall, Crystal.

In: Clinical Advances in Hematology and Oncology, Vol. 2, No. 1, 02.2005, p. 24-28.

Research output: Contribution to journalArticle

Hazra, R & Mackall, C 2005, 'Thymic function in HIV infection.', Clinical Advances in Hematology and Oncology, vol. 2, no. 1, pp. 24-28.
Hazra, Rohan ; Mackall, Crystal. / Thymic function in HIV infection. In: Clinical Advances in Hematology and Oncology. 2005 ; Vol. 2, No. 1. pp. 24-28.
@article{e0223395d9a24768aa516c935cf45d75,
title = "Thymic function in HIV infection.",
abstract = "Current models hold that CD4+ depletion occurs as a result of direct and indirect effects of HIV, which both kill peripheral CD4+ cells and prevent adequate regeneration. Although age-associated involution diminishes thymic reserve and HIV is clearly thymotoxic, clinical trials have nonetheless shown that large proportions of patients who sustain adequate control of viral replication with highly active antiretroviral therapy (HAART) will demonstrate some evidence for thymic-dependent immune reconstitution, which is associated with improved immune competence. Furthermore, patients with insufficient or absent immune reconstitution following HAART generally lack evidence for thymopoiesis. Current studies are focused on improving our understanding of the causes for thymic failure in HIV infection. Recent work has demonstrated that some HIV strains, especially those that are CXCR4 trophic, are more thymotoxic and may contribute to irreversible thymic damage in this population.",
author = "Rohan Hazra and Crystal Mackall",
year = "2005",
month = "2",
language = "English (US)",
volume = "2",
pages = "24--28",
journal = "Nature Clinical Practice Oncology",
issn = "1759-4774",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Thymic function in HIV infection.

AU - Hazra, Rohan

AU - Mackall, Crystal

PY - 2005/2

Y1 - 2005/2

N2 - Current models hold that CD4+ depletion occurs as a result of direct and indirect effects of HIV, which both kill peripheral CD4+ cells and prevent adequate regeneration. Although age-associated involution diminishes thymic reserve and HIV is clearly thymotoxic, clinical trials have nonetheless shown that large proportions of patients who sustain adequate control of viral replication with highly active antiretroviral therapy (HAART) will demonstrate some evidence for thymic-dependent immune reconstitution, which is associated with improved immune competence. Furthermore, patients with insufficient or absent immune reconstitution following HAART generally lack evidence for thymopoiesis. Current studies are focused on improving our understanding of the causes for thymic failure in HIV infection. Recent work has demonstrated that some HIV strains, especially those that are CXCR4 trophic, are more thymotoxic and may contribute to irreversible thymic damage in this population.

AB - Current models hold that CD4+ depletion occurs as a result of direct and indirect effects of HIV, which both kill peripheral CD4+ cells and prevent adequate regeneration. Although age-associated involution diminishes thymic reserve and HIV is clearly thymotoxic, clinical trials have nonetheless shown that large proportions of patients who sustain adequate control of viral replication with highly active antiretroviral therapy (HAART) will demonstrate some evidence for thymic-dependent immune reconstitution, which is associated with improved immune competence. Furthermore, patients with insufficient or absent immune reconstitution following HAART generally lack evidence for thymopoiesis. Current studies are focused on improving our understanding of the causes for thymic failure in HIV infection. Recent work has demonstrated that some HIV strains, especially those that are CXCR4 trophic, are more thymotoxic and may contribute to irreversible thymic damage in this population.

UR - http://www.scopus.com/inward/record.url?scp=25144525238&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25144525238&partnerID=8YFLogxK

M3 - Article

C2 - 16091245

AN - SCOPUS:25144525238

VL - 2

SP - 24

EP - 28

JO - Nature Clinical Practice Oncology

JF - Nature Clinical Practice Oncology

SN - 1759-4774

IS - 1

ER -