Thulium fiber laser damage to the ureter

Christopher R. Wilson, Luke A. Hardy, Pierce B. Irby, Nathaniel M. Fried

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Our laboratory is studying experimental thulium fiber laser (TFL) as a potential alternative lithotripter to the clinical gold standard Holmium:YAG laser. Safety studies characterizing undesirable Holmium laser-induced damage to ureter tissue have been previously reported. Similarly, this study characterizes TFL induced ureter and stone basket damage. A TFL beam with pulse energy of 35 mJ, pulse duration of 500 μs, and pulse rates of 150-500 Hz was delivered through a 100-μm-core, low-OH, silica optical fiber to the porcine ureter wall, in vitro. Ureter perforation times were measured and gross, histological, and optical coherence tomography images of the ablation zone were acquired. TFL operation at 150, 300, and 500 Hz produced mean ureter perforation times of 7.9, 3.8, and 1.8 s, respectively. Collateral damage averaged 510, 370, and 310 μm. TFL mean perforation time exceeded 1 s at each setting, which is a greater safety margin than previously reported during Holmium laser ureter perforation studies.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISBN (Print)9781628417074
StatePublished - 2015
Externally publishedYes
EventMedical Laser Applications and Laser Tissue Interactions VII - Munich, Germany
Duration: Jun 21 2015Jun 23 2015


OtherMedical Laser Applications and Laser Tissue Interactions VII


  • Ablation
  • Infrared, laser
  • Lithotripsy
  • Stones
  • Thulium
  • Ureter

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Wilson, C. R., Hardy, L. A., Irby, P. B., & Fried, N. M. (2015). Thulium fiber laser damage to the ureter. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9542). [95420C] SPIE.