Through-skull vasculature assessment using fluorescence brain imaging on murine models at around 800 nm

Hanh N.D. Le, Yung Tian A. Gau, Arman Rahmim, Dean F. Wong, Dwight E. Bergles, Jin U. Kang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe a scanning near-infrared fluorescence imager for through-skull non-invasive brain imaging on live murine models. The captured photoluminescence feature through scattering media was enhanced using a high sensitivity scientific CMOS sensor with the obtained spatial resolution of 15.63 μm, depth of field of 5 mm and an average local signal-to-noise ratio of 37.5 dB.

Original languageEnglish (US)
Title of host publicationNeural Imaging and Sensing
EditorsJun Ding, Qingming Luo
PublisherSPIE
ISBN (Electronic)9781510605435
DOIs
StatePublished - 2017
EventNeural Imaging and Sensing - San Francisco, United States
Duration: Jan 30 2017Jan 31 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10051
ISSN (Print)1605-7422

Other

OtherNeural Imaging and Sensing
Country/TerritoryUnited States
CitySan Francisco
Period1/30/171/31/17

Keywords

  • Brain imaging
  • Fluorescence imaging
  • Vasculature monitoring

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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