Thromboxane receptor blockade reduces renal injury in murine lupus nephritis

Robert F. Spurney, Pang Yen Fan, Phillip Ruiz, Fred Sanfilippo, David S. Pisetsky, Thomas M. Coffman

Research output: Contribution to journalArticlepeer-review

Abstract

To investigate the role of thromboxane A2 (TxA2) in murine lupus, we assessed the effects of the specific thromboxane receptor antagonist GR32191 on immune complex glomerulonephritis in MRL-lpr/lpr mice. Forty mg/kg/day GR32191 was given by twice daily subcutaneous injection for eight weeks beginning at 12 weeks of age. This dose completely blocked the renal vasoconstriction produced by the thromboxane agonist U46619. After eight weeks of treatment, both glomerular filtration rate (GFR) (8.9 ± 0.6 vs. 6.8 ± 1.1 ml/min/kg; P PAH) (37.4 ± 2.5 vs. 29.9 ± 3.3 ml/min/kg; P2 (TxB2) in urine (292 ± 37 vs. 747 ± 155 pg/24 hr; P 2 is an important mediator of renal dysfunction and injury in this murine model of lupus nephritis.

Original languageEnglish (US)
Pages (from-to)973-982
Number of pages10
JournalKidney International
Volume41
Issue number4
StatePublished - Apr 1992
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology

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