Thrombospondins in the transition from myocardial infarction to heart failure

Jonathan A. Kirk, Oscar Cingolani

Research output: Contribution to journalArticle

Abstract

The heart's reaction to ischemic injury from a myocardial infarction involves complex cross-talk between the extra-cellular matrix (ECM) and different cell types within the myocardium. The ECM functions not only as a scaffold where myocytes beat synchronously, but an active signaling environment that regulates the important post-MI responses. The thrombospondins are matricellular proteins that modulate cell - ECM interactions, functioning as "sensors" that mediate outside-in and inside-out signaling. Thrombospondins are highly expressed during embryonic stages, and although their levels decrease during adult life, can be re-expressed in high quantities in response to cardiac stress including myocardial infarction and heart failure. Like a Swiss-army knife, the thrombospondins possess many tools: numerous binding domains that allow them to interact with other elements of the ECM, cell surface receptors, and signaling molecules. It is through these that the thrombospondins function. In the present review, we provide basic as well as clinical evidence linking the thrombospondin proteins with the post myocardial infarction response, including inflammation, fibrotic matrix remodeling, angiogenesis, as well as myocyte hypertrophy, apoptosis, and contractile dysfunction in heart failure. We will describe what is known regarding the intracellular signaling pathways that are involved with these responses, paving the road for future studies identifying these proteins as therapeutic targets for cardiac disease.

Original languageEnglish (US)
Pages (from-to)102-110
Number of pages9
JournalJournal of Molecular and Cellular Cardiology
Volume90
DOIs
StatePublished - Jan 1 2016

Fingerprint

Thrombospondins
Heart Failure
Myocardial Infarction
Muscle Cells
Proteins
Cell Surface Receptors
Hypertrophy
Heart Diseases
Myocardium
Apoptosis
Inflammation
Wounds and Injuries

Keywords

  • Angiogenesis
  • Heart failure
  • Myocardial infarction
  • Remodeling
  • TGFβ
  • Thrombospondin

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Cite this

Thrombospondins in the transition from myocardial infarction to heart failure. / Kirk, Jonathan A.; Cingolani, Oscar.

In: Journal of Molecular and Cellular Cardiology, Vol. 90, 01.01.2016, p. 102-110.

Research output: Contribution to journalArticle

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