Thrombosis in Children: Approach to Anatomic Risks, Thrombophilia, Prevention, and Treatment

Research output: Contribution to journalReview article

Abstract

Pediatric venous thromboembolism (VTE) is increasing in incidence but minimal data exist for best practices regarding therapy, use of thrombophilia testing, and management of long-term complications. Classification schema use anatomic location and presence of clinical or thrombophilic inciting factors. There are a small number of risk-assessment and risk-modeling systems for incident VTE, but all suffer from low numbers, single-institution design, and lack of prospective validation. Acute treatment is limited to heparin products and thrombolysis may be indicated in specific situations. In addition, chronic postthrombotic comorbidities are expected to increase in incidence and lack evidence-based treatment paradigms.

Original languageEnglish (US)
JournalHematology/Oncology Clinics of North America
DOIs
StatePublished - Jan 1 2019

Fingerprint

Thrombophilia
Thrombosis
Venous Thromboembolism
Incidence
Practice Guidelines
Heparin
Comorbidity
Therapeutics
Pediatrics

Keywords

  • Pediatrics
  • Prevention
  • Thrombophilia
  • Treatment
  • Venous thromboembolism

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

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title = "Thrombosis in Children: Approach to Anatomic Risks, Thrombophilia, Prevention, and Treatment",
abstract = "Pediatric venous thromboembolism (VTE) is increasing in incidence but minimal data exist for best practices regarding therapy, use of thrombophilia testing, and management of long-term complications. Classification schema use anatomic location and presence of clinical or thrombophilic inciting factors. There are a small number of risk-assessment and risk-modeling systems for incident VTE, but all suffer from low numbers, single-institution design, and lack of prospective validation. Acute treatment is limited to heparin products and thrombolysis may be indicated in specific situations. In addition, chronic postthrombotic comorbidities are expected to increase in incidence and lack evidence-based treatment paradigms.",
keywords = "Pediatrics, Prevention, Thrombophilia, Treatment, Venous thromboembolism",
author = "Arash Mahajerin and Marisol Betensky and Neil Goldenberg",
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AU - Mahajerin, Arash

AU - Betensky, Marisol

AU - Goldenberg, Neil

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N2 - Pediatric venous thromboembolism (VTE) is increasing in incidence but minimal data exist for best practices regarding therapy, use of thrombophilia testing, and management of long-term complications. Classification schema use anatomic location and presence of clinical or thrombophilic inciting factors. There are a small number of risk-assessment and risk-modeling systems for incident VTE, but all suffer from low numbers, single-institution design, and lack of prospective validation. Acute treatment is limited to heparin products and thrombolysis may be indicated in specific situations. In addition, chronic postthrombotic comorbidities are expected to increase in incidence and lack evidence-based treatment paradigms.

AB - Pediatric venous thromboembolism (VTE) is increasing in incidence but minimal data exist for best practices regarding therapy, use of thrombophilia testing, and management of long-term complications. Classification schema use anatomic location and presence of clinical or thrombophilic inciting factors. There are a small number of risk-assessment and risk-modeling systems for incident VTE, but all suffer from low numbers, single-institution design, and lack of prospective validation. Acute treatment is limited to heparin products and thrombolysis may be indicated in specific situations. In addition, chronic postthrombotic comorbidities are expected to increase in incidence and lack evidence-based treatment paradigms.

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