Thrombocytopenia in pregnancy

Shruti Chaturvedi, Keith R. McCrae

Research output: Chapter in Book/Report/Conference proceedingChapter


Thrombocytopenia in pregnancy is relatively common and may have many different etiologies. While some causes of thrombocytopenia, such as incidental thrombocytopenia of pregnancy, have no impact on pregnancy outcomes, others, such as preeclampsia or the syndrome of hemolysis, elevated liver function tests, and low platelets (HELLP) adversely impact both maternal and fetal health. The latter disorders display features that overlap extensively with the primary thrombotic microangiopathies, thrombotic thrombocytopenic purpura (TTP) and the atypical hemolytic-uremic syndrome (aHUS), the incidence of which is increased in pregnancy. Distinguishing these disorders may be difficult, although it is important to do so since the definitive management of the pregnancy-specific disorders involves delivery of the fetus. Recent insights into the mechanisms underlying the diffuse endothelial dysfunction associated with preeclampsia, as well as the role of complement inhibitor gene mutations in HUS and HELLP, offer new approaches to diagnosis and management of these frequently devastating disorders.

Original languageEnglish (US)
Title of host publicationPlatelets
Number of pages18
ISBN (Electronic)9780128134566
StatePublished - Jan 1 2019


  • ITP
  • Platelets
  • Pregnancy
  • Thrombocytopenia
  • Thrombotic microangiopathy

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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