Thrombelastography and Other Novel Techniques

Udaya S. Tantry, Vijay A. Doraiswamy, Glenn Stokken, Marvin J. Slepian, Paul A. Gurbel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent implementation of user-friendly, point-of-care (POC) and near-POC platelet function assays in translational research studies enhanced interest in the personalized antiplatelet therapy concept. In addition to the measurement of platelet response to a particular agonist as measured in widely used POC platelet function assays, analyses of thrombin generation and viscoelastic characteristics of platelet-fibrin clot generation may enhance the prognostic value of the functional test. Thrombelastograph refers to the graphic display produced from measurement of the viscoelastic properties of platelet-fibrin clot generated in the whole blood under conditions of low shear. High maximum thrombin-induced platelet-fibrin clot strength and also high ADP-induced platelet-fibrin clot strength were shown to be associated with postpercutaneous coronary intervention ischemic event occurrences. Currently, there are other novel techniques under development that utilize hemodynamics, microfluidics, and nanotechnology principles such as CORA system, T2 magnetic resonance (T2MR), and shear-induced platelet aggregation assays (SIPA).

Original languageEnglish (US)
Title of host publicationAntiplatelet Therapy in Cardiovascular Disease
PublisherWiley-Blackwell
Pages102-107
Number of pages6
ISBN (Electronic)9781118493984
ISBN (Print)9781118275757
DOIs
StatePublished - Jun 3 2014

Keywords

  • CORA system
  • Platelet mapping assay
  • Platelets
  • Point-of-care assays
  • Shear-induced platelet aggregation assays
  • T2 magnetic resonance
  • Thrombelastography

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Tantry, U. S., Doraiswamy, V. A., Stokken, G., Slepian, M. J., & Gurbel, P. A. (2014). Thrombelastography and Other Novel Techniques. In Antiplatelet Therapy in Cardiovascular Disease (pp. 102-107). Wiley-Blackwell. https://doi.org/10.1002/9781118493984.ch12