Three-year visual and anatomic results of administrating intravitreal bevacizumab in inflammatory ocular neovascularization

Ahmad M. Mansour, J. Fernando Arevalo, Christine Fardeau, Emily N. Hrisomalos, Wai Man Chan, Timothy Y.Y. Lai, Focke Ziemssen, Thomas Ness, Abla Mehio Sibai, Friederike MacKensen, Armin Wolf, Nicholas Hrisomalos, Arnd Heiligenhaus, Georg Spital, Yukari Jo, Fumi Gomi, Yasushi Ikuno, Jad Akesbi, Phuc LeHoang, Alfredo AdanPadmamalini Mahendradas, Moncef Khairallah, Rainer Guthoff, Blanche Ghandour, Cem Küçükerdönmez, Shree K. Kurup

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess the 3-year visual outcome of intravitreal bevacizumab in inflammatory ocular neovascularization. Design: Experimental study. Methods: Retrospective multicenter consecutive case series in 81 patients with inflammatory ocular neovascularization refractory to standard therapy and treated with intravitreal bevacizumab. The outcome measures included improvement of best corrected visual acuity expressed as logarithm of minimum angle of resolution (logMAR) and paired comparison decrease in central foveal thickness by optical coherence tomography. Results: Mean best corrected visual acuity improved from baseline 0.699 (6/30 or 20/101) (SD 0.434) to 0.426 (6/16 or 20/53) (SD 0.428) (n = 81; p < 0.001), a gain of 2.7 lines (median 3 injections; 81 eyes; 81 patients). Paired comparisons revealed significant central foveal flattening at 3 years of 97.9 μm (n = 51; p < 0.001). In a subgroup analysis, visual improvement was significant for ocular histoplasmosis (p = 0.026); multifocal choroiditis (p = 0.05); serpiginous choroiditis (p = 0.028); ocular toxoplasmosis (p = 0.042); and punctate inner choroidopathy (p = 0.015). In a subgroup analysis, foveal flattening was significant for ocular histoplasmosis (p = 0.004); multifocal choroiditis (p = 0.007); serpiginous choroiditis (p = 0.011); and punctate inner choroidopathy (p = 0.001). Of the group, 5 eyes developed submacular fibrosis, 1 eye retinal pigment epithelial tear, and 1 eye macular ischemia in the context of vasculitis. Conclusion: At 3 years, intravitreal bevacizumab sustained significant visual improvement of 2.7 lines and significant foveal flattening of 98 μm in a wide variety of inflammatory ocular diseases without major complications after a median of 3 injections.

Original languageEnglish (US)
Pages (from-to)269-274
Number of pages6
JournalCanadian Journal of Ophthalmology
Volume47
Issue number3
DOIs
StatePublished - Jun 2012

ASJC Scopus subject areas

  • Ophthalmology

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