Three ways to die suddenly: do they all require calcium calmodulin-dependent protein kinase II?

Mark E. Anderson

Three ways to die suddenly: do they all require calcium calmodulin-dependent protein kinase II?

Mark E. Anderson

School of Medicine

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Sudden cardiac death occurs due to a limited number of pathological events. The heart can beat too fast or too slow to maintain adequate cardiac output or the heart can rupture. Here we survey recent evidence that excessive activation of calcium calmodulin-dependent protein kinase II by three core neurohumoral pathways or by oxidant stress can lead to sudden cardiac death due to sinus node dysfunction and bradycardia, ventricular tachycardia or fibrillation, and cardiac rupture.

Original language	English (US)
Pages (from-to)	173-185
Number of pages	13
Journal	Transactions of the American Clinical and Climatological Association
Volume	125
State	Published - 2014

ASJC Scopus subject areas

General Medicine

Cite this

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AB - Sudden cardiac death occurs due to a limited number of pathological events. The heart can beat too fast or too slow to maintain adequate cardiac output or the heart can rupture. Here we survey recent evidence that excessive activation of calcium calmodulin-dependent protein kinase II by three core neurohumoral pathways or by oxidant stress can lead to sudden cardiac death due to sinus node dysfunction and bradycardia, ventricular tachycardia or fibrillation, and cardiac rupture.

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Three ways to die suddenly: do they all require calcium calmodulin-dependent protein kinase II?

Abstract

ASJC Scopus subject areas

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