Three ways to die suddenly: do they all require calcium calmodulin-dependent protein kinase II?

Research output: Contribution to journalReview articlepeer-review

Abstract

Sudden cardiac death occurs due to a limited number of pathological events. The heart can beat too fast or too slow to maintain adequate cardiac output or the heart can rupture. Here we survey recent evidence that excessive activation of calcium calmodulin-dependent protein kinase II by three core neurohumoral pathways or by oxidant stress can lead to sudden cardiac death due to sinus node dysfunction and bradycardia, ventricular tachycardia or fibrillation, and cardiac rupture.

Original languageEnglish (US)
Pages (from-to)173-185
Number of pages13
JournalTransactions of the American Clinical and Climatological Association
Volume125
StatePublished - Jan 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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