Three-month pancreas graft function significantly influences survival following simultaneous pancreas-kidney transplantation in type 2 diabetes patients

Tarek Alhamad, Ryan Kunjal, Jason Wellen, Daniel C. Brennan, Alexander Wiseman, Kricia Ruano, Veronica Hicks, Mei Wang, Mark A. Schnitzler, Su Hsin Chang, Krista L. Lentine

Research output: Contribution to journalArticle

Abstract

Successful simultaneous pancreas-kidney transplantation (SPK) improves quality-of-life and prolongs kidney allograft and patient survival in type-1 diabetic (T1DM) patients. However, the use of SPK in type-2 diabetic (T2DM) patients remains limited. We examined a national transplant registry for 35 849 T2DM kidney disease patients who received transplant between 2000 and 2016 and survived the first 3 months with a functioning kidney, and categorized as: deceased-donor kidney transplant alone (DD-KA, 68%), living-donor kidney transplant alone (LD-KA, 30%), or SPK (2%). Among SPK recipients, 6% had pancreas allograft failure within 3 months (SPK,P-) and 94% had a functional pancreas (SPK,P+). Associations of transplant type with kidney allograft failure and death (multivariable-adjusted hazard ratio, 95%LCLaHR95%UCL), over follow-up through December 2018, were quantified by multivariable inverse probability of treatment weighted survival analyses. SPK recipients had better kidney graft and patient survival than LD-KA or DD-KA recipients. Compared to SPK,P+, DD-KA, or LD-KA recipients had significantly higher risk of kidney allograft failure (DD-KA: aHR 1.532.203.17; LD-KA: aHR 1.291.872.71) and death (DD-KA: aHR 2.123.255.00; LD-KA: aHR 1.542.353.59). SPK,P- recipients had significantly higher risk of death (aHR 1.683.306.50). Similar to T1DM, T2DM patients with SPK have a survival benefit compared to those with kidney transplant alone, but this benefit depends upon successful early pancreas function.

Original languageEnglish (US)
Pages (from-to)788-796
Number of pages9
JournalAmerican Journal of Transplantation
Volume20
Issue number3
DOIs
StatePublished - Mar 1 2020

Keywords

  • allograft survival
  • patient overall survival
  • registries
  • simultaneous pancreas-kidney transplantation
  • type 2 diabetes mellitus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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  • Cite this

    Alhamad, T., Kunjal, R., Wellen, J., Brennan, D. C., Wiseman, A., Ruano, K., Hicks, V., Wang, M., Schnitzler, M. A., Chang, S. H., & Lentine, K. L. (2020). Three-month pancreas graft function significantly influences survival following simultaneous pancreas-kidney transplantation in type 2 diabetes patients. American Journal of Transplantation, 20(3), 788-796. https://doi.org/10.1111/ajt.15615