Three-dimensionally patterned cardiomyocytes with high activity for powering bio-hybrid microdevices

Deok Ho Kim, Jungryul Park, Kahp Y. Suh, Pilnam Kim, Seung Kyu Choi, Sang Ho Lee, Byungkyu Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have demonstrated a simple method for patterning cardiac muscle cells with high activity on a micron scale for powering bio-hybrid microdevices. The morphology and mobility of patterned cardiac muscle cells within micro wells were analyzed with different topographical heights of the barrier. We found that three-dimensionally grown cardiac cells mediated by a higher physical harrier generated higher contraction force with fasler beating frequency than those of cells attached to the collagen-coated surface on the culture dish (control), suggesting that control over cell growth and shape would be critical for potential engineered cellular motors. Thus, the micropatterned cardiac muscle cells presented here would provide a primary platform for building up 3-D bioactuated microdevices including an engineered cell motor.

Original languageEnglish (US)
Title of host publication2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Pages233-236
Number of pages4
DOIs
StatePublished - 2005
Externally publishedYes
Event2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology - Oahu, HI, United States
Duration: May 12 2005May 15 2005

Publication series

Name2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Volume2005

Conference

Conference2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
CountryUnited States
CityOahu, HI
Period5/12/055/15/05

Keywords

  • Bio-hybrid microdevice
  • Bioactuator
  • Capillary lithography
  • Cardiac muscles
  • Cell patterning

ASJC Scopus subject areas

  • Engineering(all)

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