Three-dimensional whole-heart T2 mapping at 3T

Haiyan Ding, Laura Fernandez-De-Manuel, Michael Schär, Karl H. Schuleri, Henry Halperin, Le He, M. Muz Zviman, Roy Beinart, Daniel A. Herzka

Research output: Contribution to journalArticlepeer-review


Purpose Detecting variations in myocardial water content with T2 mapping is superior to conventional T2-weighted MRI since quantification enables direct observation of complicated pathology. Most commonly used T2 mapping techniques are limited in achievable spatial and/or temporal resolution, both of which reduce accuracy due to partial-volume averaging and misregistration between images. The goal of this study was to validate a novel free breathing T2 mapping sequence that overcomes these limitations. Methods The proposed technique was made insensitive to heart rate variability through the use of a saturation prepulse to reset magnetization every heartbeat. Respiratory navigator-gated, differentially T2-weighted volumes were interleaved per heartbeat, guaranteeing registered images and robust voxel-by-voxel T2 maps. Free breathing acquisitions removed limits on spatial resolution and allowed short diastolic windows. Accuracy was quantified with simulations and phantoms. Results Homogeneous three-dimensional (3D) T2 maps were obtained from normal human subjects and swine. Normal human and swine left ventricular T2 values were 42.3±4.0 and 43.5±4.3 ms, respectively. The T2 value for edematous myocardium obtained from a swine model of acute myocardial infarction was 59.1±7.1 ms. Conclusion Free-breathing accurate 3D T2 mapping is feasible and may be applicable in myocardial assessment in lieu of current clinical black blood, T2-weighted techniques. Magn Reson Med 74:803-816, 2015.

Original languageEnglish (US)
Pages (from-to)803-816
Number of pages14
JournalMagnetic resonance in medicine
Issue number3
StatePublished - Sep 1 2015


  • 3D
  • T mapping
  • T relaxation time
  • cardiac magnetic resonance imaging
  • free breathing
  • relaxometry

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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