Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging

Susumu Mori; Barbara J. Crain; V. P. Chacko; Peter C.M. Van Zijl

doi:10.1002/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3

Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging

Susumu Mori, Barbara J. Crain, V. P. Chacko, Peter C.M. Van Zijl

School of Medicine

Research output: Contribution to journal › Article › peer-review

2744 Scopus citations

Abstract

The relationship between brain structure and complex behavior is governed by large-scale neurocognitive networks. The availability of a noninvasive technique that can visualize the neuronal projections connecting the functional centers should therefore provide new keys to the understanding of brain function. By using high-resolution three-dimensional diffusion magnetic resonance imaging and a newly designed tracking approach, we show that neuronal pathways in the rat brain can be probed in situ. The results are validated through comparison with known anatomical locations of such fibers.

Original language	English (US)
Pages (from-to)	265-269
Number of pages	5
Journal	Annals of neurology
Volume	45
Issue number	2
DOIs	https://doi.org/10.1002/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3
State	Published - 1999

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3

Cite this

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Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging

Abstract

ASJC Scopus subject areas

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