Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging

Susumu Mori, Barbara J. Crain, V. P. Chacko, Peter C.M. Van Zijl

Research output: Contribution to journalArticle

Abstract

The relationship between brain structure and complex behavior is governed by large-scale neurocognitive networks. The availability of a noninvasive technique that can visualize the neuronal projections connecting the functional centers should therefore provide new keys to the understanding of brain function. By using high-resolution three-dimensional diffusion magnetic resonance imaging and a newly designed tracking approach, we show that neuronal pathways in the rat brain can be probed in situ. The results are validated through comparison with known anatomical locations of such fibers.

Original languageEnglish (US)
Pages (from-to)265-269
Number of pages5
JournalAnnals of neurology
Volume45
Issue number2
DOIs
StatePublished - Feb 16 1999

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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