Three-dimensional printing of tissue phantoms for biophotonic imaging

Jianting Wang, James Coburn, Chia Pin Liang, Nicholas Woolsey, Jessica C. Ramella-Roman, Yu Chen, T. Joshua Pfefer

Research output: Contribution to journalArticle

Abstract

We have investigated the potential of tissue phantoms fabricated with thermosoftening- and photopolymerizationbased three-dimensional (3D) printers for use in evaluation of biophotonic imaging systems. The optical properties of printed polymer samples were measured and compared to biological tissues. Phantoms with subsurface channels as small as 0.2 mm in diameter were fabricated and imaged with microscopy, x-ray microtomography, and optical coherence tomography to characterize morphology. These phantoms were then implemented to evaluate the penetration depth of a hyperspectral reflectance imaging system used in conjunction with a near-infrared contrast agent. Results indicated that 3D printing may provide a suitable platform for performance testing in biophotonics, although subsurface imaging is critical to mitigate printer-to-printer variability in matrix homogeneity and feature microstructure.

Original languageEnglish (US)
Pages (from-to)3010-3013
Number of pages4
JournalOptics Letters
Volume39
Issue number10
DOIs
StatePublished - May 15 2014
Externally publishedYes

Fingerprint

Imaging Phantoms
printers
printing
Optical Coherence Tomography
Contrast Media
Microscopy
Polymers
X-Rays
homogeneity
penetration
platforms
tomography
microscopy
reflectance
optical properties
microstructure
evaluation
polymers
matrices
Three Dimensional Printing

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Medicine(all)

Cite this

Wang, J., Coburn, J., Liang, C. P., Woolsey, N., Ramella-Roman, J. C., Chen, Y., & Joshua Pfefer, T. (2014). Three-dimensional printing of tissue phantoms for biophotonic imaging. Optics Letters, 39(10), 3010-3013. https://doi.org/10.1364/OL.39.003010

Three-dimensional printing of tissue phantoms for biophotonic imaging. / Wang, Jianting; Coburn, James; Liang, Chia Pin; Woolsey, Nicholas; Ramella-Roman, Jessica C.; Chen, Yu; Joshua Pfefer, T.

In: Optics Letters, Vol. 39, No. 10, 15.05.2014, p. 3010-3013.

Research output: Contribution to journalArticle

Wang, J, Coburn, J, Liang, CP, Woolsey, N, Ramella-Roman, JC, Chen, Y & Joshua Pfefer, T 2014, 'Three-dimensional printing of tissue phantoms for biophotonic imaging', Optics Letters, vol. 39, no. 10, pp. 3010-3013. https://doi.org/10.1364/OL.39.003010
Wang J, Coburn J, Liang CP, Woolsey N, Ramella-Roman JC, Chen Y et al. Three-dimensional printing of tissue phantoms for biophotonic imaging. Optics Letters. 2014 May 15;39(10):3010-3013. https://doi.org/10.1364/OL.39.003010
Wang, Jianting ; Coburn, James ; Liang, Chia Pin ; Woolsey, Nicholas ; Ramella-Roman, Jessica C. ; Chen, Yu ; Joshua Pfefer, T. / Three-dimensional printing of tissue phantoms for biophotonic imaging. In: Optics Letters. 2014 ; Vol. 39, No. 10. pp. 3010-3013.
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