Three-dimensional plus time biventricular strain from tagged MR images by phase-unwrapped harmonic phase

Bharath Ambale Venkatesh, Chun G. Schiros, Himanshu Gupta, Steven G. Lloyd, Louis Dell'Italia, Thomas S. Denney

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To validate a method called bi-ventricular strain unwrapped phase (BiSUP) for reconstructing three-dimensional plus time (3D+t) biventricular strain maps from phase-unwrapped harmonic phase (HARP) images derived from tagged cardiac magnetic resonance imaging (MRI). Materials and Methods: A set of 30 human subjects were imaged with tagged MRI. In each study, HARP phase was computed and unwrapped in each short-axis and long-axis image. Inconsistencies in unwrapped phase were resolved using branch cuts manually placed with a graphical user interface. The 3D strain maps were computed independently in each imaged time frame through systole and mid diastole in each study. The BiSUP strain and displacements were compared with those estimated by a 3D feature-based (FB) technique and a 2D+t HARP technique. Results: The standard deviation of the difference between strains measured by the FB and the BiSUP methods was less than 4% of the average of the strains from the two methods. The correlation between peak minimum principal strain measured using the BiSUP and HARP techniques was over 83%. Conclusion: The BiSUP technique can reconstruct full 3D+t strain maps from tagged MR images through the cardiac cycle in a reasonable amount of time and user interaction compared with other 3D analysis methods.

Original languageEnglish (US)
Pages (from-to)799-810
Number of pages12
JournalJournal of Magnetic Resonance Imaging
Volume34
Issue number4
DOIs
StatePublished - Oct 2011
Externally publishedYes

Keywords

  • 4D strain
  • biventricular strain
  • branch cuts
  • harmonic phase
  • phase unwrapping
  • tagged magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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