Three-dimensional heat-induced echo-strain imaging for monitoring high-intensity acoustic ablation

Emad M. Boctor, Nishikant Deshmukh, S. Ayad Maria, Clyde Clarke, Kris Dickie, Michael A. Choti, Everette C. Burdette

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


Three dimensional heat-induced echo-strain imaging is a potentially useful tool for monitoring the formation of thermal lesions during ablative therapy. Heat-induced echo-strain, known as thermal strain, is due to the changes in the speed of propagating ultrasound signals and to tissue expansion during heat deposition. This paper presents a complete system for targeting and intraoperative monitoring of thermal ablation by high intensity focused acoustic applicators. A special software interface has been developed to enable motor motion control of 3D mechanical probes and rapid acquisition of 3D-RF data (ultrasound raw data after the beam-forming unit). Ex-vivo phantom and tissue studies were performed in a controlled laboratory environment. While B-mode ultrasound does not clearly identify the development of either necrotic lesions or the deposited thermal dose, the proposed 3D echo-strain imaging can visualize these changes, demonstrating agreement with temperature sensor readings and gross-pathology. Current results also demonstrate feasibility for realtime computation through a parallelized implementation for the algorithm used. Typically, 125 frames per volume can be processed in less than a second. We also demonstrate motion compensation that can account for shift within frames due to either tissue movement or positional error in the US 3D imaging probe.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2009
Subtitle of host publicationUltrasonic Imaging and Signal Processing
StatePublished - 2009
Externally publishedYes
EventMedical Imaging 2009: Ultrasonic Imaging and Signal Processing - Lake Buena Vista, FL, United States
Duration: Feb 8 2009Feb 9 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2009: Ultrasonic Imaging and Signal Processing
Country/TerritoryUnited States
CityLake Buena Vista, FL


  • 3D ultrasound
  • Ablation monitoring
  • Echo-strain
  • High intensity focused ultrasound (HIFU)
  • Parallelization
  • Therapy
  • Thermal imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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