Three-dimensional functional magnetic resonance imaging of human brain on a clinical 1.5-T scanner

Peter Van Gelderen, Nick F. Ramsey, Guoying Liu, Jeff H. Duyn, Joseph A. Frank, Daniel Weinberger, Chrit T.W. Moonen

Research output: Contribution to journalArticle


Functional magnetic resonance imaging (fMRI) is a tool for mapping brain function that utilizes neuronal activity-induced changes in blood oxygenation. An efficient three-dimensional fMR1 method is presented for imaging brain activity on conventional, widely available, 1.5-T scanners, without additional hardware. This approach uses large magnetic susceptibility weighting based on the echo-shifting principle combined with multiple gradient echoes per excitation. Motor stimulation, induced by self-paced finger tapping, reliably produced significant signal increase in the hand region of the contralateral primary motor cortex in every subject tested.

Original languageEnglish (US)
Pages (from-to)6906-6910
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number15
Publication statusPublished - Jul 18 1995
Externally publishedYes


ASJC Scopus subject areas

  • General

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