Three-dimensional diffusion tensor magnetic resonance microimaging of adult mouse brain and hippocampus

Research output: Contribution to journalArticle

Abstract

The use of diffusion tensor information as an additional contrast in MR microimaging was investigated in ex vivo mouse brain and isolated hippocampus. Diffusion Tensor Imaging (DTI) provided unique contrast to identify many internal structures of the gray matter such as hippocampus, thalamus, and cortex. In hippocampus, stratum granulosum and stratum pyramidale could be identified using the isotropic water diffusion constant. Stratum moleculare and stratum radiatum were identified from their characteristic fiber architecture revealed by color-coded DTI. Identification of these structures allowed reconstruction of their 3-D volume. Thus, high-resolution DTI has excellent potential as a tool for 3-D characterization of murine brains.

Original languageEnglish (US)
Article number91012
Pages (from-to)892-901
Number of pages10
JournalNeuroImage
Volume15
Issue number4
DOIs
StatePublished - Jan 1 2002

Keywords

  • Brain
  • DTI
  • Hippocampus
  • Mouse

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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