Three-dimensional cell cultures as a model system to evaluate the biological activity of gemcitabine (2',2'-difluoro-2'deoxycytidine)

G. J. Peters, E. Smitskamp-Wilms, G. Veerman, P. E. Pizao, V. W T Ruiz van Haperen, H. M. Pinedo

Research output: Contribution to journalArticlepeer-review

Abstract

The cytotoxicity of Gemcitabine (dFdC) was 10 (ovarian cancer) to > 10,000 (colon cancer) fold higher in monolayer compared to three-dimensional multilayer cell cultures. This selectivity was related to marked differences in dFdC activation and effects on ribonucleotides.

Original languageEnglish (US)
Pages (from-to)661-664
Number of pages4
JournalNucleosides and Nucleotides
Volume14
Issue number3-5
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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