The cytotoxicity of Gemcitabine (dFdC) was 10 (ovarian cancer) to > 10,000 (colon cancer) fold higher in monolayer compared to three-dimensional multilayer cell cultures. This selectivity was related to marked differences in dFdC activation and effects on ribonucleotides.
|Original language||English (US)|
|Number of pages||4|
|Journal||Nucleosides and Nucleotides|
|State||Published - 1995|
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