Three decades of the Human Genome Organization

Charles Lee, Stylianos E. Antonarakis, Ada Hamosh, John Burn

Research output: Contribution to journalArticlepeer-review


The Human Genome Organization (HUGO) was initially established in 1988 to help integrate international scientific genomic activity and to accelerate the diffusion of knowledge from the efforts of the human genome project. Its founding President was Victor McKusick. During the late 1980s and 1990s, HUGO organized lively gene mapping meetings to accurately place genes on the genome as chromosomes were being sequenced. With the completion of the Human Genome Project, HUGO went through some transitions and self-reflection. In 2020, HUGO (which hosts a large annual scientific meeting and comprises the renowned HUGO Gene Nomenclature Committee [HGNC], responsible for naming genes, and an outstanding Ethics Committee) was merged with the Human Genome Variation Society (HGVS; which defines the correct nomenclature for variation description) and the Human Variome Project (HVP; championed by the late Richard Cotton) into a single organization that is committed to assembling human genomic variation from all over the world. This consolidated effort, under a new Executive Board and seven focused committees, will facilitate efficient and effective communication and action to bring the benefits of increasing knowledge of genome diversity and biology to people all over the world.

Original languageEnglish (US)
Pages (from-to)3314-3321
Number of pages8
JournalAmerican Journal of Medical Genetics, Part A
Issue number11
StatePublished - Nov 2021


  • HGNC
  • HGVS
  • HVP
  • Human Genome Organization
  • genome biology
  • international

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


Dive into the research topics of 'Three decades of the Human Genome Organization'. Together they form a unique fingerprint.

Cite this