TY - JOUR
T1 - Three additional inositol 1,4,5-trisphosphate receptors
T2 - Molecular cloning and differential localization in brain and peripheral tissues
AU - Ross, Christopher A.
AU - Danoff, Sonye K.
AU - Schell, Michael J.
AU - Snyder, Solomon H.
AU - Ullrich, Axel
PY - 1992
Y1 - 1992
N2 - Three inositol 1,4,5-trisphosphate receptor (IP3R) cDNAs, designated IP3R-II, -III, and -IV, were cloned homology a mouse placenta cDNA library. All three display strong originally in membrane-spanning domains M7 and M8 to the inantly cloned cerebellar IP3R-I, with divergences predominantly in cytoplasmic domains. Levels of mRNA for the three additional IP3Rs in general are substantially lower than for IP3R-I, though in the gastrointestinal tract the levels of IP3R-III may be comparable to IP3R-I. Cerebellar Purkinje cells express at least two and possibly three distinct IP3Rs, suggesting hrterogeneity of IP3 action within a single cell.
AB - Three inositol 1,4,5-trisphosphate receptor (IP3R) cDNAs, designated IP3R-II, -III, and -IV, were cloned homology a mouse placenta cDNA library. All three display strong originally in membrane-spanning domains M7 and M8 to the inantly cloned cerebellar IP3R-I, with divergences predominantly in cytoplasmic domains. Levels of mRNA for the three additional IP3Rs in general are substantially lower than for IP3R-I, though in the gastrointestinal tract the levels of IP3R-III may be comparable to IP3R-I. Cerebellar Purkinje cells express at least two and possibly three distinct IP3Rs, suggesting hrterogeneity of IP3 action within a single cell.
KW - Cerebellar purkinje cells
KW - Intracellular calcium
KW - Plasma membrane
KW - Second messengers
KW - T lymphocytes
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U2 - 10.1073/pnas.89.10.4265
DO - 10.1073/pnas.89.10.4265
M3 - Article
C2 - 1374893
AN - SCOPUS:0026508615
VL - 89
SP - 4265
EP - 4269
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 10
ER -