Three additional inositol 1,4,5-trisphosphate receptors: Molecular cloning and differential localization in brain and peripheral tissues

Christopher A. Ross, Sonye K. Danoff, Michael J. Schell, Solomon H. Snyder, Axel Ullrich

Research output: Contribution to journalArticlepeer-review

Abstract

Three inositol 1,4,5-trisphosphate receptor (IP3R) cDNAs, designated IP3R-II, -III, and -IV, were cloned homology a mouse placenta cDNA library. All three display strong originally in membrane-spanning domains M7 and M8 to the inantly cloned cerebellar IP3R-I, with divergences predominantly in cytoplasmic domains. Levels of mRNA for the three additional IP3Rs in general are substantially lower than for IP3R-I, though in the gastrointestinal tract the levels of IP3R-III may be comparable to IP3R-I. Cerebellar Purkinje cells express at least two and possibly three distinct IP3Rs, suggesting hrterogeneity of IP3 action within a single cell.

Original languageEnglish (US)
Pages (from-to)4265-4269
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number10
DOIs
StatePublished - 1992

Keywords

  • Cerebellar purkinje cells
  • Intracellular calcium
  • Plasma membrane
  • Second messengers
  • T lymphocytes

ASJC Scopus subject areas

  • General

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