Three additional inositol 1,4,5-trisphosphate receptors: Molecular cloning and differential localization in brain and peripheral tissues

Christopher A. Ross; Sonye K. Danoff; Michael J. Schell; Solomon H. Snyder; Axel Ullrich

doi:10.1073/pnas.89.10.4265

Three additional inositol 1,4,5-trisphosphate receptors: Molecular cloning and differential localization in brain and peripheral tissues

Christopher A. Ross, Sonye K. Danoff, Michael J. Schell, Solomon H. Snyder, Axel Ullrich

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Three inositol 1,4,5-trisphosphate receptor (IP₃R) cDNAs, designated IP₃R-II, -III, and -IV, were cloned homology a mouse placenta cDNA library. All three display strong originally in membrane-spanning domains M7 and M8 to the inantly cloned cerebellar IP₃R-I, with divergences predominantly in cytoplasmic domains. Levels of mRNA for the three additional IP₃Rs in general are substantially lower than for IP₃R-I, though in the gastrointestinal tract the levels of IP₃R-III may be comparable to IP₃R-I. Cerebellar Purkinje cells express at least two and possibly three distinct IP₃Rs, suggesting hrterogeneity of IP₃ action within a single cell.

Original language	English (US)
Pages (from-to)	4265-4269
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	89
Issue number	10
DOIs	https://doi.org/10.1073/pnas.89.10.4265
State	Published - 1992

Keywords

Cerebellar purkinje cells
Intracellular calcium
Plasma membrane
Second messengers
T lymphocytes

ASJC Scopus subject areas

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10.1073/pnas.89.10.4265

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Three additional inositol 1,4,5-trisphosphate receptors : Molecular cloning and differential localization in brain and peripheral tissues. / Ross, Christopher A.; Danoff, Sonye K.; Schell, Michael J.; Snyder, Solomon H.; Ullrich, Axel.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, No. 10, 1992, p. 4265-4269.

Research output: Contribution to journal › Article › peer-review

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abstract = "Three inositol 1,4,5-trisphosphate receptor (IP3R) cDNAs, designated IP3R-II, -III, and -IV, were cloned homology a mouse placenta cDNA library. All three display strong originally in membrane-spanning domains M7 and M8 to the inantly cloned cerebellar IP3R-I, with divergences predominantly in cytoplasmic domains. Levels of mRNA for the three additional IP3Rs in general are substantially lower than for IP3R-I, though in the gastrointestinal tract the levels of IP3R-III may be comparable to IP3R-I. Cerebellar Purkinje cells express at least two and possibly three distinct IP3Rs, suggesting hrterogeneity of IP3 action within a single cell.",

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Three additional inositol 1,4,5-trisphosphate receptors: Molecular cloning and differential localization in brain and peripheral tissues

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Keywords

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