Three additional inositol 1,4,5-trisphosphate receptors: Molecular cloning and differential localization in brain and peripheral tissues

Christopher A. Ross; Sonye K. Danoff; Michael J. Schell; Solomon H. Snyder; Axel Ullrich

doi:10.1073/pnas.89.10.4265

Three additional inositol 1,4,5-trisphosphate receptors: Molecular cloning and differential localization in brain and peripheral tissues

Christopher A. Ross, Sonye K. Danoff, Michael J. Schell, Solomon H. Snyder, Axel Ullrich

Research output: Contribution to journal › Article › peer-review

217 Scopus citations

Abstract

Three inositol 1,4,5-trisphosphate receptor (IP₃R) cDNAs, designated IP₃R-II, -III, and -IV, were cloned homology a mouse placenta cDNA library. All three display strong originally in membrane-spanning domains M7 and M8 to the inantly cloned cerebellar IP₃R-I, with divergences predominantly in cytoplasmic domains. Levels of mRNA for the three additional IP₃Rs in general are substantially lower than for IP₃R-I, though in the gastrointestinal tract the levels of IP₃R-III may be comparable to IP₃R-I. Cerebellar Purkinje cells express at least two and possibly three distinct IP₃Rs, suggesting hrterogeneity of IP₃ action within a single cell.

Original language	English (US)
Pages (from-to)	4265-4269
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	89
Issue number	10
DOIs	https://doi.org/10.1073/pnas.89.10.4265
State	Published - 1992
Externally published	Yes

Keywords

Cerebellar purkinje cells
Intracellular calcium
Plasma membrane
Second messengers
T lymphocytes

ASJC Scopus subject areas

General

Access to Document

10.1073/pnas.89.10.4265

Cite this

Three additional inositol 1,4,5-trisphosphate receptors : Molecular cloning and differential localization in brain and peripheral tissues. / Ross, Christopher A.; Danoff, Sonye K.; Schell, Michael J. et al.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, No. 10, 1992, p. 4265-4269.

Research output: Contribution to journal › Article › peer-review

@article{3db23060e80c435eb4df3701c21e066d,

title = "Three additional inositol 1,4,5-trisphosphate receptors: Molecular cloning and differential localization in brain and peripheral tissues",

abstract = "Three inositol 1,4,5-trisphosphate receptor (IP3R) cDNAs, designated IP3R-II, -III, and -IV, were cloned homology a mouse placenta cDNA library. All three display strong originally in membrane-spanning domains M7 and M8 to the inantly cloned cerebellar IP3R-I, with divergences predominantly in cytoplasmic domains. Levels of mRNA for the three additional IP3Rs in general are substantially lower than for IP3R-I, though in the gastrointestinal tract the levels of IP3R-III may be comparable to IP3R-I. Cerebellar Purkinje cells express at least two and possibly three distinct IP3Rs, suggesting hrterogeneity of IP3 action within a single cell.",

keywords = "Cerebellar purkinje cells, Intracellular calcium, Plasma membrane, Second messengers, T lymphocytes",

author = "Ross, {Christopher A.} and Danoff, {Sonye K.} and Schell, {Michael J.} and Snyder, {Solomon H.} and Axel Ullrich",

year = "1992",

doi = "10.1073/pnas.89.10.4265",

language = "English (US)",

volume = "89",

pages = "4265--4269",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "10",

}

TY - JOUR

T1 - Three additional inositol 1,4,5-trisphosphate receptors

T2 - Molecular cloning and differential localization in brain and peripheral tissues

AU - Ross, Christopher A.

AU - Danoff, Sonye K.

AU - Schell, Michael J.

AU - Snyder, Solomon H.

AU - Ullrich, Axel

PY - 1992

Y1 - 1992

N2 - Three inositol 1,4,5-trisphosphate receptor (IP3R) cDNAs, designated IP3R-II, -III, and -IV, were cloned homology a mouse placenta cDNA library. All three display strong originally in membrane-spanning domains M7 and M8 to the inantly cloned cerebellar IP3R-I, with divergences predominantly in cytoplasmic domains. Levels of mRNA for the three additional IP3Rs in general are substantially lower than for IP3R-I, though in the gastrointestinal tract the levels of IP3R-III may be comparable to IP3R-I. Cerebellar Purkinje cells express at least two and possibly three distinct IP3Rs, suggesting hrterogeneity of IP3 action within a single cell.

AB - Three inositol 1,4,5-trisphosphate receptor (IP3R) cDNAs, designated IP3R-II, -III, and -IV, were cloned homology a mouse placenta cDNA library. All three display strong originally in membrane-spanning domains M7 and M8 to the inantly cloned cerebellar IP3R-I, with divergences predominantly in cytoplasmic domains. Levels of mRNA for the three additional IP3Rs in general are substantially lower than for IP3R-I, though in the gastrointestinal tract the levels of IP3R-III may be comparable to IP3R-I. Cerebellar Purkinje cells express at least two and possibly three distinct IP3Rs, suggesting hrterogeneity of IP3 action within a single cell.

KW - Cerebellar purkinje cells

KW - Intracellular calcium

KW - Plasma membrane

KW - Second messengers

KW - T lymphocytes

UR - http://www.scopus.com/inward/record.url?scp=0026508615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026508615&partnerID=8YFLogxK

U2 - 10.1073/pnas.89.10.4265

DO - 10.1073/pnas.89.10.4265

M3 - Article

C2 - 1374893

AN - SCOPUS:0026508615

VL - 89

SP - 4265

EP - 4269

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 10

ER -

Three additional inositol 1,4,5-trisphosphate receptors: Molecular cloning and differential localization in brain and peripheral tissues

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this