Thoracic aortic distensibility and thoracic aortic calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA])

Mouaz H. Al-Mallah, Khurram Nasir, Ronit Katz, Junichiro Takasu, Joao Lima, David A. Bluemke, Gregory Hundley, Roger S Blumenthal, Matthew J. Budoff

Research output: Contribution to journalArticle

Abstract

Decreased arterial distensibility is an early manifestation of adverse structural and functional changes within the vessel wall. Its correlation with thoracic aortic calcium (TAC), a marker of atherosclerosis, has not been well demonstrated. We tested the hypothesis that decreasing aortic compliance and increasing arterial stiffness would be independently associated with increased TAC. We included 3,540 subjects (61 ± 10 years, 46% men) from the Multi-ethnic Study of Atherosclerosis who had undergone an aortic distensibility (AD) assessment using magnetic resonance imaging. TAC was calculated using a modified Agatston algorithm on noncontrast cardiac computed tomographic scans. Multivariate regression models were calculated for the presence of TAC. Overall, 861 subjects (24%) had detectable TAC. Lower AD was observed among those with versus without TAC (2.02 ± 1.34 vs 1.28 ± 0.74, p

Original languageEnglish (US)
Pages (from-to)575-580
Number of pages6
JournalThe American Journal of Cardiology
Volume106
Issue number4
DOIs
StatePublished - Aug 15 2010

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Atherosclerosis
Thorax
Calcium
Vascular Stiffness
Compliance
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Thoracic aortic distensibility and thoracic aortic calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA]). / Al-Mallah, Mouaz H.; Nasir, Khurram; Katz, Ronit; Takasu, Junichiro; Lima, Joao; Bluemke, David A.; Hundley, Gregory; Blumenthal, Roger S; Budoff, Matthew J.

In: The American Journal of Cardiology, Vol. 106, No. 4, 15.08.2010, p. 575-580.

Research output: Contribution to journalArticle

Al-Mallah, Mouaz H. ; Nasir, Khurram ; Katz, Ronit ; Takasu, Junichiro ; Lima, Joao ; Bluemke, David A. ; Hundley, Gregory ; Blumenthal, Roger S ; Budoff, Matthew J. / Thoracic aortic distensibility and thoracic aortic calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA]). In: The American Journal of Cardiology. 2010 ; Vol. 106, No. 4. pp. 575-580.
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AU - Lima, Joao

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