Thoracic aorta calcification detected by electron beam tomography predicts all-cause mortality

Raul D. Santos, John A. Rumberger, Matthew J. Budoff, Leslee J. Shaw, Sarwar H. Orakzai, Daniel Berman, Paolo Raggi, Roger S Blumenthal, Khurram Nasir

Research output: Contribution to journalArticle

Abstract

Background: The presence of coronary artery calcium (CAC) is an independent marker of increased risk of cardiovascular disease (CVD) events and mortality. However, the predictive value of thoracic aorta calcification (TAC), which can be additionally identified without further scanning during assessment of CAC, is unknown. Methods: We followed a cohort of 8401 asymptomatic individuals (mean age: 53 ± 10 years, 69% men) undergoing cardiac risk factor evaluation and TAC and CAC testing with electron beam computed tomography. Multivariable Cox proportional hazards models were developed to predict all-cause mortality based on the presence of TAC. Results: During a median follow-up period of 5 years, 124 (1.5%) deaths were observed. Overall survival was 96.9% and 98.9% for those with and without detectable TAC, respectively (p <0.0001). Compared to those with no TAC, the hazard ratio for mortality in the presence of TAC was 3.25 (95% CI: 2.28-4.65, p <0.0001) in unadjusted analysis. After adjusting for age, gender, hypertension, dyslipidemia, diabetes mellitus, smoking and family history of premature coronary artery disease, and presence of CAC the relationship remained robust (HR 1.61, 95% CI: 1.10-2.27, p = 0.015). Likelihood ratio χ2 statistics demonstrated that the addition of TAC contributed significantly in predicting mortality to traditional risk factors alone (χ2 = 13.62, p = 0.002) as well as risk factors + CAC (χ2 = 5.84, p = 0.02) models. Conclusion: In conclusion, the presence of TAC was associated with all-cause mortality in our study; this relationship was independent of conventional CVD risk factors as well as the presence of CAC.

Original languageEnglish (US)
Pages (from-to)131-135
Number of pages5
JournalAtherosclerosis
Volume209
Issue number1
DOIs
StatePublished - Mar 2010

Fingerprint

X Ray Computed Tomography
Thoracic Aorta
Coronary Vessels
Mortality
Calcium
Cardiovascular Diseases
Dyslipidemias
Proportional Hazards Models
Coronary Artery Disease
Diabetes Mellitus
Smoking
Hypertension
Survival

Keywords

  • Atherosclerosis
  • Coronary calcification
  • Electron beam tomography
  • Mortality
  • Risk factors
  • Thoracic aorta calcification

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Santos, R. D., Rumberger, J. A., Budoff, M. J., Shaw, L. J., Orakzai, S. H., Berman, D., ... Nasir, K. (2010). Thoracic aorta calcification detected by electron beam tomography predicts all-cause mortality. Atherosclerosis, 209(1), 131-135. https://doi.org/10.1016/j.atherosclerosis.2009.08.025

Thoracic aorta calcification detected by electron beam tomography predicts all-cause mortality. / Santos, Raul D.; Rumberger, John A.; Budoff, Matthew J.; Shaw, Leslee J.; Orakzai, Sarwar H.; Berman, Daniel; Raggi, Paolo; Blumenthal, Roger S; Nasir, Khurram.

In: Atherosclerosis, Vol. 209, No. 1, 03.2010, p. 131-135.

Research output: Contribution to journalArticle

Santos, RD, Rumberger, JA, Budoff, MJ, Shaw, LJ, Orakzai, SH, Berman, D, Raggi, P, Blumenthal, RS & Nasir, K 2010, 'Thoracic aorta calcification detected by electron beam tomography predicts all-cause mortality', Atherosclerosis, vol. 209, no. 1, pp. 131-135. https://doi.org/10.1016/j.atherosclerosis.2009.08.025
Santos, Raul D. ; Rumberger, John A. ; Budoff, Matthew J. ; Shaw, Leslee J. ; Orakzai, Sarwar H. ; Berman, Daniel ; Raggi, Paolo ; Blumenthal, Roger S ; Nasir, Khurram. / Thoracic aorta calcification detected by electron beam tomography predicts all-cause mortality. In: Atherosclerosis. 2010 ; Vol. 209, No. 1. pp. 131-135.
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abstract = "Background: The presence of coronary artery calcium (CAC) is an independent marker of increased risk of cardiovascular disease (CVD) events and mortality. However, the predictive value of thoracic aorta calcification (TAC), which can be additionally identified without further scanning during assessment of CAC, is unknown. Methods: We followed a cohort of 8401 asymptomatic individuals (mean age: 53 ± 10 years, 69{\%} men) undergoing cardiac risk factor evaluation and TAC and CAC testing with electron beam computed tomography. Multivariable Cox proportional hazards models were developed to predict all-cause mortality based on the presence of TAC. Results: During a median follow-up period of 5 years, 124 (1.5{\%}) deaths were observed. Overall survival was 96.9{\%} and 98.9{\%} for those with and without detectable TAC, respectively (p <0.0001). Compared to those with no TAC, the hazard ratio for mortality in the presence of TAC was 3.25 (95{\%} CI: 2.28-4.65, p <0.0001) in unadjusted analysis. After adjusting for age, gender, hypertension, dyslipidemia, diabetes mellitus, smoking and family history of premature coronary artery disease, and presence of CAC the relationship remained robust (HR 1.61, 95{\%} CI: 1.10-2.27, p = 0.015). Likelihood ratio χ2 statistics demonstrated that the addition of TAC contributed significantly in predicting mortality to traditional risk factors alone (χ2 = 13.62, p = 0.002) as well as risk factors + CAC (χ2 = 5.84, p = 0.02) models. Conclusion: In conclusion, the presence of TAC was associated with all-cause mortality in our study; this relationship was independent of conventional CVD risk factors as well as the presence of CAC.",
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T1 - Thoracic aorta calcification detected by electron beam tomography predicts all-cause mortality

AU - Santos, Raul D.

AU - Rumberger, John A.

AU - Budoff, Matthew J.

AU - Shaw, Leslee J.

AU - Orakzai, Sarwar H.

AU - Berman, Daniel

AU - Raggi, Paolo

AU - Blumenthal, Roger S

AU - Nasir, Khurram

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N2 - Background: The presence of coronary artery calcium (CAC) is an independent marker of increased risk of cardiovascular disease (CVD) events and mortality. However, the predictive value of thoracic aorta calcification (TAC), which can be additionally identified without further scanning during assessment of CAC, is unknown. Methods: We followed a cohort of 8401 asymptomatic individuals (mean age: 53 ± 10 years, 69% men) undergoing cardiac risk factor evaluation and TAC and CAC testing with electron beam computed tomography. Multivariable Cox proportional hazards models were developed to predict all-cause mortality based on the presence of TAC. Results: During a median follow-up period of 5 years, 124 (1.5%) deaths were observed. Overall survival was 96.9% and 98.9% for those with and without detectable TAC, respectively (p <0.0001). Compared to those with no TAC, the hazard ratio for mortality in the presence of TAC was 3.25 (95% CI: 2.28-4.65, p <0.0001) in unadjusted analysis. After adjusting for age, gender, hypertension, dyslipidemia, diabetes mellitus, smoking and family history of premature coronary artery disease, and presence of CAC the relationship remained robust (HR 1.61, 95% CI: 1.10-2.27, p = 0.015). Likelihood ratio χ2 statistics demonstrated that the addition of TAC contributed significantly in predicting mortality to traditional risk factors alone (χ2 = 13.62, p = 0.002) as well as risk factors + CAC (χ2 = 5.84, p = 0.02) models. Conclusion: In conclusion, the presence of TAC was associated with all-cause mortality in our study; this relationship was independent of conventional CVD risk factors as well as the presence of CAC.

AB - Background: The presence of coronary artery calcium (CAC) is an independent marker of increased risk of cardiovascular disease (CVD) events and mortality. However, the predictive value of thoracic aorta calcification (TAC), which can be additionally identified without further scanning during assessment of CAC, is unknown. Methods: We followed a cohort of 8401 asymptomatic individuals (mean age: 53 ± 10 years, 69% men) undergoing cardiac risk factor evaluation and TAC and CAC testing with electron beam computed tomography. Multivariable Cox proportional hazards models were developed to predict all-cause mortality based on the presence of TAC. Results: During a median follow-up period of 5 years, 124 (1.5%) deaths were observed. Overall survival was 96.9% and 98.9% for those with and without detectable TAC, respectively (p <0.0001). Compared to those with no TAC, the hazard ratio for mortality in the presence of TAC was 3.25 (95% CI: 2.28-4.65, p <0.0001) in unadjusted analysis. After adjusting for age, gender, hypertension, dyslipidemia, diabetes mellitus, smoking and family history of premature coronary artery disease, and presence of CAC the relationship remained robust (HR 1.61, 95% CI: 1.10-2.27, p = 0.015). Likelihood ratio χ2 statistics demonstrated that the addition of TAC contributed significantly in predicting mortality to traditional risk factors alone (χ2 = 13.62, p = 0.002) as well as risk factors + CAC (χ2 = 5.84, p = 0.02) models. Conclusion: In conclusion, the presence of TAC was associated with all-cause mortality in our study; this relationship was independent of conventional CVD risk factors as well as the presence of CAC.

KW - Atherosclerosis

KW - Coronary calcification

KW - Electron beam tomography

KW - Mortality

KW - Risk factors

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