TY - JOUR
T1 - Thiophene derivatives
T2 - A new series of potent norepinephrine and serotonin reuptake inhibitors
AU - Zhang, Ao
AU - Zhou, Guochun
AU - Rong, Suo Bao
AU - Johnson, Kenneth M.
AU - Zhang, Mei
AU - Kozikowski, Alan P.
N1 - Funding Information:
Financial support from the NIH, National Institute on Drug Abuse (DA11548 and DA10458), is gratefully acknowledged. We also thank Dr. Werner Tueckmantel for his assistance in the preparation of the manuscript.
PY - 2002/4/8
Y1 - 2002/4/8
N2 - A series of (1S,3S,6R,10S)-(Z)-9-(thienylmethylene- or substituted thienylmethylene)-7-azatricyclo[4.3.1.03,7]decanes was prepared and evaluated for the ability to block dopamine, serotonin, and norepinephrine reuptake by their respective transporters. Compound 5b is a NET-selective inhibitor, 5c is a mixed NET- and SERT-selective inhibitor, while 11 is a SERT-selective inhibitor.
AB - A series of (1S,3S,6R,10S)-(Z)-9-(thienylmethylene- or substituted thienylmethylene)-7-azatricyclo[4.3.1.03,7]decanes was prepared and evaluated for the ability to block dopamine, serotonin, and norepinephrine reuptake by their respective transporters. Compound 5b is a NET-selective inhibitor, 5c is a mixed NET- and SERT-selective inhibitor, while 11 is a SERT-selective inhibitor.
UR - http://www.scopus.com/inward/record.url?scp=0037041191&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037041191&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(02)00103-8
DO - 10.1016/S0960-894X(02)00103-8
M3 - Article
C2 - 11909701
AN - SCOPUS:0037041191
SN - 0960-894X
VL - 12
SP - 993
EP - 995
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 7
ER -