Harry K. Charles, Norman A. Blum, Stephen D. Wajer, Cathy A. Leathersich, C. Lynne Burek, Julian P. Smith

Research output: Contribution to journalArticle


A team from APL and The Johns Hopkins University School of Hygiene and Public health has recently discovered that thin layers of indium and tin, coated with appropriate antigens (or antibodies), will respond visibly in white light when exposed to solutions containing a matching antibody (or antigen). The characteristics of the indium films and the tin films responsible for producing optimum visual responses in this immunoassay process are not yet well understood. The primary focus of the current project is to produce thin films of indium and tin (and their associated oxides and alloys) with controlled thicknesses and known microstructures suitable for immunoassay testing. Emphasis is on correlating fundamental thin-film properties with the strength and quality of the immunoassay visual response. All immunoassay evaluations have been conducted with the antigen human immunoglobulin (IgG), a protein found in the blood.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalJohns Hopkins APL Technical Digest (Applied Physics Laboratory)
Issue number1
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

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    Charles, H. K., Blum, N. A., Wajer, S. D., Leathersich, C. A., Burek, C. L., & Smith, J. P. (1988). THIN INDIUM AND TIN FILMS FOR IMMUNOASSAY APPLICATIONS. Johns Hopkins APL Technical Digest (Applied Physics Laboratory), 9(1), 11-15.