Thermotropic Behavior of Aqueous Dispersions of Glucosylceramide-Dipalmitoylphosphatidylcholine Mixtures

Yechezkel Barenholz, T. E. Thompson, Ernesto Freire, Maria C. Correa-Freire, Diana Bach, Israel R. Miller

Research output: Contribution to journalArticle

Abstract

Differential scanning calorimetry has been carried out on aqueous dispersions of multilamellar liposomes formed from mixtures of glucosylceramide and dipalmitoylphosphatidylcholine. The phase diagram constructed from data obtained from dispersions in excess water in the cooling mode is simpler than the diagram obtained from data obtained in the heating mode. The essentially horizontal portion of the solidus curve up to 60% glucosylceramide indicates lateral phase separation in the gel phase. The existence of a metastable region of glucosylceramide seen in the heating scans at system concentrations greater than 90% of this component is reminiscent of the complex thermal behavior of pure glucosylceramide dispersions in excess water.

Original languageEnglish (US)
Pages (from-to)3497-3501
Number of pages5
JournalBiochemistry
Volume22
Issue number14
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • Biochemistry

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    Barenholz, Y., Thompson, T. E., Freire, E., Correa-Freire, M. C., Bach, D., & Miller, I. R. (1983). Thermotropic Behavior of Aqueous Dispersions of Glucosylceramide-Dipalmitoylphosphatidylcholine Mixtures. Biochemistry, 22(14), 3497-3501. https://doi.org/10.1021/bi00283a029