Thermoregulation and hormone replacement in postmenopausal women

N. Gupta, Steven Mark Frank, N. Ghoneim, H. K. El-Rahmany, M. A. Talamini, Howard A Zacur, Srinivasa Naga Raja

Research output: Contribution to journalArticle

Abstract

To determine the thermoregulatory effects of hormone replacement in postmenopausal women, we measured core, skin, mean body temperatures, vasomotor changes, metabolic heat production, and sweat rate during warm and cold thermal challenges. The shivering to vasodilation interthreshold range was smaller in women taking estrogen (0.8 ± 0.2°C) than in women taking no hormones (1.5 ± 0.2°C, P = 0.02). The vasodilation threshold was lower in the estrogen group (36.4 ± 0.2°C) than in the no hormone (37.0 ± 0.3°C, P = 0.04) and combined estrogen/progesterone (36.9 ± 0.1°C, P = 0.03) groups. Baseline core temperature was higher in women on combined estrogen/progesterone therapy (37.5 ± 0.1°C) compared to those on no hormones (37.0 ± 0.2°C, P = 0.02) or estrogen alone (36.9 ± 0.1°C, P = 0.004). Estrogen therapy in postmenopausal women lowers heat response thresholds and narrows the interthreshold response range for thermoregulation. Adding progesterone to estrogen therapy elevates the heat response thresholds and increases core temperature setpoint.

Original languageEnglish (US)
Pages (from-to)165-169
Number of pages5
JournalJournal of Thermal Biology
Volume25
Issue number1-2
DOIs
StatePublished - Feb 2000

Fingerprint

Body Temperature Regulation
thermoregulation
estrogens
Estrogens
hormones
Hormones
Progesterone
progesterone
vasodilation
Hot Temperature
Vasodilation
Body Temperature Changes
Shivering
heat
sweat
therapeutics
skin temperature
Temperature
Sweat
Thermogenesis

Keywords

  • Core temperature
  • Estrogen
  • Postmenopausal
  • Progesterone
  • Shivering
  • Thermoregulation
  • V asoconstriction
  • Vasodilation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physiology

Cite this

Thermoregulation and hormone replacement in postmenopausal women. / Gupta, N.; Frank, Steven Mark; Ghoneim, N.; El-Rahmany, H. K.; Talamini, M. A.; Zacur, Howard A; Raja, Srinivasa Naga.

In: Journal of Thermal Biology, Vol. 25, No. 1-2, 02.2000, p. 165-169.

Research output: Contribution to journalArticle

Gupta, N. ; Frank, Steven Mark ; Ghoneim, N. ; El-Rahmany, H. K. ; Talamini, M. A. ; Zacur, Howard A ; Raja, Srinivasa Naga. / Thermoregulation and hormone replacement in postmenopausal women. In: Journal of Thermal Biology. 2000 ; Vol. 25, No. 1-2. pp. 165-169.
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