Thermographic investigation of tumor size, and its correlation to tumor relative temperature, in mice with transplantable solid breast carcinoma

Michal Tepper, Asaf Shoval, Oshrit Hoffer, Hila Confino, Michael Schmidt, Itzhak Kelson, Yona Keisari, Israel Gannot

Research output: Contribution to journalArticlepeer-review

Abstract

Treating cancer is one of the major challenges of modern medicine. Since mice models are an important tool in cancer treatment research, it is required to assess murine tumor development. Existing methods for investigating tumor development are either high cost and limited by their availability or suffer from low accuracy and reproducibility. In order to overcome these drawbacks, thermography may be used. DA3 breast cancer carcinoma tumors in 12 Balb̈Mc mice were thermally imaged and monitored for a period of several weeks. Eight mice were treated with diffusing alpha emitters radiation therapy (DaRT) wires, while four were treated with inert wires. For large tumors, the area was estimated by analyzing thermal images and was found to be in correlation with manual caliper measurements. In addition, the correlation between tumor area and relative temperatures was calculated and compared to previous works. Temperature differences were larger for tumors treated with DaRT wires than tumors with inert wires. These correlations can be used to assist in tumor size estimation and reveal information regarding its metabolic state. Overall, thermography was shown to be a promising tool for assessing tumor development with the additional advantages of being nonradiative and potentially providing indication of intratumoral biological processes. . 2013 Society of Photo-Optical Instrumentation Engineers (SPIE).

Original languageEnglish (US)
Article number111410
JournalJournal of biomedical optics
Volume18
Issue number11
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Thermography
  • biomedical optics
  • biophotonics
  • infrared imaging
  • medical imaging
  • thermal imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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